摘要
目的了解蚌埠地区喹诺酮类抗菌药物致药品不良反应(ADR)的发生情况。方法对2009年1月～2010年12月蚌埠地区上报的喹诺酮类抗菌药物致ADR报告,按性别、年龄、给药途径、药品类别、ADR涉及器官或系统及临床表现等进行统计、分析。结果 ADR涉及的喹诺酮类抗菌药物共11种,659例次,发生频次以左氧氟沙星(269例,占40.82%)居首位,其次为氧氟沙星和环丙沙星;主要的ADR类型为皮肤及其附件损害;有2例严重ADR。结论应规范喹诺酮类抗菌药物的临床应用,严格掌握其适应症、禁忌症及用法用量,以减少ADR的发生率。
Objective To investigate the situation about ADR of quinolones antibiotics in Bengbu city.Methods According to gender,age,drug administration route,drug category,organs or systems that are involved with ADR,clinical manifestations,and so on,statistically analyze reports of quinolones antibiotics drug adverse reactions in Bengbu city reported from Jan 2009 to Dec 2010.Results 11 kinds of quinolones antibiotics drugs were involved in ADR for 659 cases.ADR most occurred in levofloxacin antibiotics（269 cases,accounted for 40.82% of the total） that followed by ofloxacin and ciprofloxacin.Primary ADR type was skin and its accessory structures harm,which occurred 2 serious ADR cases.Conclusion For the purpose of reduction in ADR incidence,we should take standardization on clinical appliance of quinolones antibiotics drug,and strictly predominate its indications,contraindications,usage and dosage.
出处
《中国药事》
CAS
2011年第11期1150-1152,共3页
Chinese Pharmaceutical Affairs
基金
蚌埠市科技局资助科研项目
编号201003022
