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非小细胞肺癌脑转移46例立体定向放射治疗 被引量:1

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摘要 目的分析非小细胞肺癌(NSCLC)脑转移立体定向精确放射治疗(SRS)近期疗效。方法46例明确诊断的NSCLC脑转移患者,全部接受单纯SRS。40%~85%剂量曲线完全包裹大体肿瘤靶区(GTV)勾画,计划靶区(PTV)紧贴肿瘤外缘,不进行外放(PTV=GTV),PTV边缘处方剂量1200-2500cGy,放疗后加用保护胃黏膜药物、脱水剂、激素等对症支持治疗,降低放射性脑水肿并发症发生。结果46例患者随访3~28个月,中位随访时间12个月,3例随访期内出现新发转移灶,2例出现放射性脑水肿,1例瘤体稳定无进展,随访期内疗效:完全缓解(CR)率60.87%(28/46),部分缓解(PR)率32.61%(15/46),有效(CR+PR)率3.48%,稳定(SD)率13.04%(6/46),神经功能症状改善率93.48%(43/46),全组病例1年生存率43.5%(20/46),2年生存率13.0%(6/46)。结论SRS脑转移瘤,放疗不良反应轻微。能有效控制转移病灶,迅速改善脑神经功能症状,提高生活质量,是晚期肺癌患者出现脑转移后一种比较理想的治疗手段。
出处 《肿瘤研究与临床》 CAS 2011年第11期784-786,共3页 Cancer Research and Clinic
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