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恶性肿瘤患者伴发高钙血症15例并文献复习 被引量:8

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摘要 目的分析恶性肿瘤伴发高钙血症的临床特点、应用唑来膦酸治疗的临床疗效和安全性。方法15例有临床症状的恶性肿瘤伴发高钙血症患者应用唑来膦酸4mg静脉滴注15min治疗,观察其近期疗效、不良反应及复发、生存情况:结果15例血清钙浓度在3.25-4.25mmol/L的患者,均有可观察的临床症状,经唑来膦酸治疗,14例血清钙降至正常值、临床症状缓解,有效率达93.3%。未见严重的不良反应。中位生存期1.2个月。结论恶性肿瘤患者伴发高钙血症临床症状严重,预后差,唑来膦酸是治疗的有效药物。
作者 符炜 顾丽梅
出处 《肿瘤研究与临床》 CAS 2011年第11期775-776,共2页 Cancer Research and Clinic
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参考文献9

  • 1Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronalen in the treatment of hyperealcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. Clin Oneol, 2001, 19: 558-567.
  • 2Kawada K, Minami H, Okabe K, et al. A muhicenter and open label clinical trial of zoledronic acid 4 mg in patients with hypercalcemia of malignancy. Jpn J Clin Oncol, 2005, 35: 28-33.
  • 3申戈,宋三泰,江泽飞,卞寿庚,谢广茹,王雅杰,王杰军.唑来磷酸治疗恶性肿瘤引起高钙血症的临床研究[J].中华肿瘤杂志,2005,27(10):632-634. 被引量:18
  • 4曹军宁,许立功,俞雄,张秀平,张君玮.帕米膦酸二钠Ⅲ期临床试验报告[J].中国癌症杂志,1999,9(1):77-80. 被引量:21
  • 5Wellington K, Goa KL. Zoledionic acid: a review of its use in the management of bone metastases and hypercalcemia of malignancy. Drugs, 2003, 63: 417-437.
  • 6邸立军,任军,冯奉仪,谢广茹,秦叔逵,胡晓桦,姚晨.国产唑来膦酸治疗肿瘤高钙血症多中心Ⅱ期临床观察[J].中国肿瘤临床,2006,33(18):1032-1034. 被引量:8
  • 7Li EC, Davis LE. Zoledronic acid: a new parenteral bisphosphonate. Clin Rapeutics, 2003, 25: 2669-2708.
  • 8Pan BQ, To LB, Farrugia AN, et al. The nitrogen-containing bisphosphonate, zoledronia acid, increases mineralization of human bong--derived cells in vitro. Bone, 2004, 34:112-123.
  • 9田慎.唑来膦酸治疗骨转移癌35例近期疗效观察[J].肿瘤研究与临床,2006,18(8):565-566. 被引量:2

二级参考文献23

  • 1周美珍,伍健宇,胡亚军,李文举,许佩珉.恶性肿瘤伴发高钙血症5例[J].中国癌症杂志,1996,6(1):24-26. 被引量:1
  • 2Stewart AF, Horst R, Deftos LJ, et al. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med, 1980,303 : 1377-1383.
  • 3Mundy GR, lbbotson K J, DSouza SM, et al. The hypercalcemia of cancer. Clinical implications and pathogenic mechanisms. N Engl J Med, 1984, 310:1718-1727.
  • 4Fisken RA, Heath DA, Bold AM. Hypercalcemia: a hospital survey. O J Med,1980,49:405-418.
  • 5Blomqvist CP. Malignant hypercalcemia: a hospital survey. Acta Med Scand, 1986,220:455-463.
  • 6Burt ME, Brennan MF. Incidence of hypercalcemia and malignant neoplasm. Arch Surg, 1980,115:704-707.
  • 7Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol,2001,19:558-567.
  • 8Wellington K, Goa KL. Zoledronic acid: a review of its use in the management of bone metastases and hypercalcaemia of malignancy-Drugs, 2003,63:417-437.
  • 9Berenson JR. Treatment of hypercalcemia of malignancy with bisphosphonates. Semin Oncol. 2002,29(6 Suppl 21):12-18.
  • 10Geng Z,Monier-Faugere M C,Bauss F,et al.Short-term administration of the bisphosphonate ibandronate increases bone volume and prevents by perparathyroad bone changes in mild inexperimental renal failure[J].Clin Nephrol,2000,54(1):45.

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