摘要
目的探讨趋化因子及其受体CXCR4和缺氧诱导因子-1α（HIF-1α）在食管鳞状上皮癌中的表达及其与食管鳞状细胞癌临床病理特征的关系及临床意义。方法采用免疫组织化学SP法检测56例食管鳞状细胞癌组织和20例癌旁正常黏膜组织中CXCR4和HIF-1α的表达情况。结果食管鳞状细胞癌组织中CXCR4、HIF-1α的阳性表达率分别为62．50％（35／56）、57．14％（32／56），均明显高于正常组织的10．00％（2／20）、0（0／20）（χ^2=16．259、19．740，均P〈0．01）；CXCR4和HIF-1α在食管鳞状细胞癌组织中的表达与浸润深度及淋巴结转移有关（CXCR4：χ^2=4．736、7．665与HIF-1α：χ^2=7．207、6．389，均P〈0．05），与癌组织分化程度无关；CXCR4和HIF-1α在食管鳞状细胞癌组织中的表达呈正相关（r=0．298，P〈0．05）。结论CXCR4和HIF-1α在食管鳞状细胞癌中高表达；二者可能与食管鳞状细胞癌的生长、侵袭、转移密切相关。
Objective To investigate the expression and clinicopathological significance of CXCR4 and HIF-1α protein in esophageal sqaamous cell carcinoma tissue and explore their correlation. Methods The expression of CXCR4 and HIF-1α protein were assessed by immunohistochemistry SP method in 56 cases with esophageal squamous cell carcinoma and in 20 cases with surrounded normal tissue. Results The expressions of CXCR4 and HIF-1α in esophageal squamous cell carcinoma were significantly higher than those in normal tissues [62.50 % （35/56） vs 10.00 % （2/20）; 57.14 % （32/56） vs 0（0/20）] （χ^2=16.259, 19.740, P 〈0.01）. The expression of CXCR4 and HIF-1α were both correlated with invasion depth （χ^ 2 = 4,736, 7,665, P 〈0.05） and lymph node metastasis （χ^2 = 7.207, 6.389, P 〈0.05）, and had no correlation with cancer cell differentiation. The expressions of CXCR4 and HIF-1α in esophageal squamous cell carcinoma were positively correlated （r =0.298, P 〈0.05）. Conclusion CXCR4 and HIF-1α are highly expressed in esophageal squamous cell carcinoma. The two have a close relation to esophageal squamous cell carcinoma growth, invasion and metastasis.
出处
《肿瘤研究与临床》
CAS
2011年第11期772-774,共3页
Cancer Research and Clinic
