摘要
目的探讨血清瘦素及人体质量指数（BMI）与食管鳞状细胞癌的相关性，为食管癌的防治寻找科学依据。方法收集2009年12月到2010年11月间山西省肿瘤医院胸外二科食管鳞状细胞癌患者47例，以20名健康人为对照，采用酶联免疫吸附法测定血清瘦素水平，分析其与临床病理因素的关系及危险眭。结果鳞状细胞癌患者及健康人血清瘦素水平分别为（13．09±5．94）和（7．58±4．16）ng／ml，差异有统计学意义（t=3．76，P=0．001）。47例患者BMI、清蛋白、淋巴细胞数分别为（25．20±3．14）kg／m^2、（43．58±2．15）g／L和（2．02±0．55）×10^9／L，其中血清瘦素水平与BMI呈正相关（r=0．561，P=0．006），与清蛋白、淋巴细胞数无相关性（r=0．206，P=0．242；r=0．122，P=0．412），不同临床分期间及有无淋巴结转移者间血清瘦素水平差异均无统计学意义（F=1．325，P=0．281；t=-0．595，P=0．556）。Logistic回归分析显示，随瘦素水平的增高食管鳞状细胞癌的发病危险性升高（OR=1．442，P=0．009）。结论瘦素水平的升高可能是食管鳞状细胞癌发生的一个危险因子。
Objective To explore the relationship of serum leptin concentration, body mass index （BMI） and esophageal squamous cell carcinoma. Methods Blood samples were collected from 47 patients with esophageal squamous cell carcinoma and 20 healthy controls in Shanxi Cancer Hospital. Serum leptin was measured by ELISA. Results Serum leptin concentration in patients group was significantly higher than control group [（13.09±5.94） ng/ml vs （7.58±4.16） ng/ml, （t = 3.76, P=0.001）]. In 47 patients, BMI, albumin and lymphocytes were （25.20±3.14） kg/m2, （43.58±2.15）g/L and （2.02±0.55）×10^9/L, respectively. The serum leptin concentration of all patients （47 cases） were positive correlation with BMI （r = 0.561, P = 0.006）, not with blood albumin and lymphocytes （r= 0.206, P = 0.242; r = 0.122, P= 0.412）. Multiple logistic regression analysis reveal statistically significant association between serum leptin and esophageal squamous cell carcinoma incidence （OR =1.442, 95 % CI 1.094-1.848, P = 0.09）. Conclusion Higher serum leptin levels seem to represent an additional and independent risk factor for esophageal squamous cell carcinoma.
出处
《肿瘤研究与临床》
CAS
2011年第11期759-761,共3页
Cancer Research and Clinic
关键词
瘦素
人体质量指数
食管肿瘤
肿瘤
鳞状细胞
Leptin
Body mass index
Esophageal neoplasms
Neoplasms, squamous cell
