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椎间盘退变相关基因单核苷酸多态性的研究进展 被引量：3

Single nucleotide polymorphism of genes associated with intervertebral disc degeneration:recent progress
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摘要 椎间盘退变具有一定程度的遗传易感性,可能与人群中存在基因多态性有关。近年来,椎间盘退变与基因单核苷酸多态性的相关性研究逐渐增加并取得长足进展,目前研究的基因主要包括3类:(1)与椎间盘稳定性相关的基因,包括结构相关基因和代谢相关基因;(2)炎症相关基因;(3)疼痛信号通路相关基因。研究椎间盘退变相关基因单核苷酸多态性将有助于揭示椎间盘退变的遗传学机制,从而为个性化预防和治疗椎间盘退变疾病开辟新的道路。 Genetic susceptibility exists in intervertebral disc degeneration（IDD） diseases,which may be associated with gene polymorphisms.Recently,much progress has been made in the relationship between IDD susceptibility and gene single nucleotide polymorphism（SNP）.The genes associated with IDD mainly include 3 types： genes associated with intervertebral disc stability（about structure and metabolism）,genes associated with inflammation,and genes associated with pain signal channel.Studies of SNP in genes associated with IDD can help to identify its molecular mechanism,paving a way for individualized prevention and treatment of IDD.
作者 程勇军 沈洪兴
机构地区 第二军医大学长海医院骨科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2011年第11期1244-1248,共5页 Academic Journal of Second Military Medical University
基金 军队"十一五"医药卫生科研基金(06MA163)~~
关键词 椎间盘退变 基因 单核苷酸多态性 intervertebral disc degeneration gene single nucleotide polymorphism
分类号 R681.53 [医药卫生—骨科学]
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参考文献33

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二级参考文献10

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共引文献13

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二级引证文献10

第二军医大学学报
2011年 第11期

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