摘要
慢性阻塞性肺疾病(COPD)患者存在诸多影响骨质代谢的因素,导致骨质疏松的发生,严重威胁着患者的身心健康。其中吸烟、低氧血症与高碳酸血症、营养不良与低体重、糖皮质激素的应用、免疫及细胞因子的作用、血液高凝状态、废用性萎缩等都起到一定的作用。可以将骨质疏松当作COPD肺外疾病表现考虑,也可以认为COPD是骨质疏松的危险因素。尽管慢性阻塞性肺疾病合并骨质疏松的机制尚未完全明确,但了解二者的相关性对于指导临床治疗,提高慢性阻塞性肺疾病患者的生存质量有重要意义。
Many factors affecting bone metabolism exist in the chronic obstructive pulmonary disease （COPD）. These factors can induce osteoporosis and seriously threaten the health of the patients. Among others, smoking, hypoxemia and hypercapnia, malnutrition and low weight, glucocorticoid application, immunity and cytokines, high coagulation status, and atrophy due to disuse play certain role. Osteoporosis can be considered as the extra pulmonary disease of COPD, or COPD can be considered as the risk factor of osteoporosis. Although the mechanism of chronic obstructive pulmonary disease accompanied by osteoporosis is not completely clarified, a thorough understanding of the relationship between COPD and osteoporosis is significant for clinical treatment and improvement of life quality of COPD patients.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第11期1033-1036,共4页
Chinese Journal of Osteoporosis
