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肺移植术后血清HMGB1水平的变化及其临床意义 被引量：5

Clinical significance of serum HMGB1 determination after lung transplantation
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摘要 目的探讨血清高迁移率族蛋白B1(HMGB1)水平在肺移植术后的变化和临床意义。方法肺移植21例,其中术后稳定者10例、术后发生急性排斥反应5例、肺部感染6例。采用酶联免疫吸附试验(ELISA)对19名健康者和肺移植患者术前、术后第1、3、7天的血清HMGB1水平进行检测。结果肺移植术后患者血清HMGB1水平明显升高,急性排斥反应组术后第7天血清HMGB1水平明显高于稳定组(P<0.01),肺部感染组术后第3天和术后第7天的血清HMGB1水平均明显高于稳定组和急性排斥反应组。健康对照组血清HMGB1水平明显低于肺移植患者术前水平(P<0.01)。结论肺移植术后血清HMGB1水平升高,血清HMGB1检测对肺移植术后并发症诊断有较好价值。 Objective To investigate the change of serum HMGB1 level after lung transplantation and its clinical significance.Methods 21 patients were divided into stable group（n=10）,acute rejection group（n=5） and infected group（n=6） according to the complications after lung transplantation.Serum HMGB1 level was determinated in 19 healthy cases and 21 patients at the preoperative day,1st day,3rd day and 7th day after lung transplantation by ELISA.Results Serum HMGB1 level was markedly increased after lung transplantation.Serum HMGB1 level of acute rejection group was significantly higher than that of stable group at 7th day（P〈0.01）.Serum HMGB1 level of infected group was significantly higher compared with stable group and acute rejection group at 3rd day and 7th day.Conclusion Serum HMGB1 level was significantly elevated after lung transplantation.The determination of serum HMGB1 is significant to the laboratory diagnosis of complications after lung transplantation.
作者 王发龙 陈静瑜 胡志刚 陈国千
机构地区 南京医科大学附属无锡人民医院医学检验科 南京医科大学附属无锡人民医院胸外科
出处 《中国实验诊断学》 北大核心 2011年第11期1857-1858,共2页 Chinese Journal of Laboratory Diagnosis
基金 国家自然科学基金(81070074/H0116)
关键词 高迁移率族蛋白B1 肺移植 血清 high mobility group box 1 lung transplantation serum
分类号 R655.3 [医药卫生—外科学]
  • 相关文献

参考文献8

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二级参考文献19

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共引文献9

同被引文献47

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引证文献5

二级引证文献20

中国实验诊断学
2011年 第11期

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