摘要
为了研究不同因素对片剂释药速率的影响,并通过药效试验确定最佳配方,以樟脑和薰衣草精油为主要防蛀成分,以紫茎泽兰为辅料,粉末直接压片法制片,通过动态释放试验测定不同影响因素下片剂的释药速率,并以黑皮蠹为供试虫种,测定纯樟脑、纯紫茎泽兰草粉以及不同配方制剂的防蛀效果。结果表明:紫茎泽兰草粉可压性良好;10MPa制片压力下,以二氧化硅吸附薰衣草精油制得的片剂,对精油的缓释效果最好。纯樟脑片和纯草粉片的织物损害程度分别为3级、4级,均未达到登记标准(≤2);当樟脑含量为60%,精油含量为6%时,片剂防蛀效果最好,织物损害程度为1级,满足并超过登记标准。
The mothproofing tablets composed of dry eupatorium powder,lavender oil and camphor were prepared.The effects of various factors on the release rates of active agents from the mothproofing tablets were investigated.The optimized formulation was obtained by efficacy test.The camphor and lavender oil-containing mothproofing tablets were prepared by the method of direct compression using eupatorium dry powders as a matrix material.The factors influencing the release rates of active agents from the tablets were investigated using in vitro dynamic release experiment.The efficacies of pure camphor tablets,pure dry eupatorium-powder tablets and the other tablets with different formulations were evaluated using the black carpet beetles as test insects.The dry eupatorium powders had good compressibility.The tablets had good sustained release effects for lavender oil,which were prepared under the compression force of 10MPa using silica particles as the adsorbent for lavender oil.The fabric damage degree was evaluated as grade 3 and 4 respectively for pure camphor tablets and pure eupatorium-powder tablets,both of which did not meet the registration standard （grade≤2）.The formulations were optimized to obtain the best efficacy when the mass fraction of camphor was 60% （m/m） and the mass fraction of lavender oil was 6% （m/m） and the remaining fraction was dry eupatorium powder.The fabric damage degree of this optimized formulation was grade 1,meeting even excelling the registration standard.
出处
《中国农学通报》
CSCD
北大核心
2011年第25期82-88,共7页
Chinese Agricultural Science Bulletin
基金
"恶性外来入侵植物紫茎泽兰防控与利用技术研究与示范"子项目(200803021-012)
