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多发性硬化灰质病变研究进展 被引量：2

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摘要 中枢神经灰质病变在多发性硬化发病机制中具有重要地位,其病理、影像等特征与神经功能障碍密切相关。多模态MRI技术对于灰质病变检测具有较高的敏感性和特异性,为相关研究提供了重要手段。除继发性轴突和神经元损伤、凋亡等机制外,新近证实接触素2介导的双重免疫反应在灰质损伤中发挥关键作用,相关进展可能改变多发性硬化的防治策略。
作者 刘辉 曲方
机构地区 解放军第 沈阳军区总医院神经内科
出处 《国际神经病学神经外科学杂志》 2011年第5期471-474,共4页 Journal of International Neurology and Neurosurgery
关键词 多发性硬化 灰质 磁共振成像 发病机制
分类号 R744.51 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献25

  • 1龚霞蓉,包颜明,田伟.弥散张量成像在认知功能中的研究现状[J].国际神经病学神经外科学杂志,2010,37(3):286-289. 被引量：5
  • 2李波,刘宁宁,檀国军.多发性硬化和实验性自身免疫性脑脊髓炎中的轴突损伤[J].国际神经病学神经外科学杂志,2009,36(3):271-275. 被引量：2
  • 3Antonio Giorgio,Nicola Stefano.Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy[J]. Neurological Sciences . 2010 (2)
  • 4Tobias Derfuss,Chris Linington,Reinhard Hohlfeld,Edgar Meinl.Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury[J]. Journal of Molecular Medicine . 2010 (8)
  • 5Birgit Simon,Stephan Schmidt,Carsten Lukas,Jürgen Gieseke,Frank Tr?ber,Dirk L. Knol,Winfried A. Willinek,Jeroen J. G. Geurts,Hans H. Schild,Frederik Barkhof,Mike P. Wattjes.Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla[J]. European Radiology . 2010 (7)
  • 6Filippi M,,Rocca MA.MR imaging of gray matter involve-ment in multiple sclerosis:Implications for understanding dis-ease pathophysiology and monitoring treatment efficacy. American Journal of Neuroradiology . 2010
  • 7Sicotte NL.Neuroimaging in multiple sclerosis:neurothera-peutic implications. Neurotherapeutics . 2011
  • 8Steinman L.The gray aspects of white matter disease in multi-ple sclerosis. Proceedings of the National Academy of Sciences of the United States of America . 2009
  • 9Zhang Y,Metz LM,Yong VW,et al.3T deep gray matter T2hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis:a3-year pilot study. Journal of the Neurological Sciences . 2010
  • 10Schmierer K,Parkes HG,So PW,et al.High field(9.4 Tesla)magnetic resonance imaging of cortical grey matter le-sions in multiple sclerosis. Brain . 2010

二级参考文献28

  • 1Linker RA, Sendtner M, Gold R. Mechanisms of axonal degeneration in EAE--lessons from CNTF and MHC I knockout mice. J Neurol Sci, 2005, 233(1-2) : 167-172.
  • 2Charcot JM. Histologie de la sclerose en plaques. Gazette H ? pitaux, 1868b, 41 (566) : 557-558.
  • 3Hauser SL, Oksenberg JR. The neurobiology of multiple scle- rosis : genes, inflammation, and neurodegeneration. Neuron, 2006, 52 (1) : 61 -76.
  • 4Sherman DL, Tait S, Melrose S. Neurofascins are required to establish axonal domains for salutatory conduction. Neuron, 2005, 48(5) : 737-742.
  • 5Mathey EK, Derfuss T, Storch MK, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med, 2007, 204(10): 2363-2372.
  • 6Maggs FG, Palace J. The pathogenesis of multiple sclerosis: is it really a primary inflammatory process? Mult Scler, . 2004, 10(3) : 326-329.
  • 7Tsunoda I, Tanaka T, Terry EJ. Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis. Am J Pathol, 2007, 170(1) : 214-226.
  • 8Pascual AM, Martinez Bisbal MC, Bosca I, et al. Axonal loss is progressive and partly dissociated from lesion load in early multiple sclerosis. Neurology, 2007, 69 ( 1 ) : 63-67.
  • 9De Vfies GH. Cryptic axonal antigens and axonal loss in multiple sclerosis. Neurochem Res, 2004, 29 ( 11 ) : 1999- 2006.
  • 10Kassmann CM, Lappe Siefke C, Baes M, et al. Axonal loss and neuroinfiammation caused by peroxisome-deficient oligodendrocytes. Nat Genet, 2007 , 39 ( 8 ) : 969-976.

共引文献5

同被引文献18

  • 1曹翠丽,马常升,阎蕴力,杨天祝,李学平.实验性变态反应性脑脊髓炎大鼠丛上细胞扫描电镜观察[J].解剖学杂志,2003,26(6):591-594. 被引量：1
  • 2付文祥.细胞凋亡与自身免疫病[J].免疫学杂志,2005,21(B06):85-88. 被引量：4
  • 3董梅,刘瑞春,郭力,李春岩.Wistar大鼠多病程实验性变态反应性脑脊髓炎的模型建立[J].中国免疫学杂志,2006,22(1):78-81. 被引量：12
  • 4郑建筝,高聪,谢富华,蒲蜀湘,陈盛强.SD大鼠实验性变态反应性脑脊髓炎模型的建立[J].实用诊断与治疗杂志,2006,20(7):469-472. 被引量：10
  • 5Mancardi G, Hart B A, Capello E, et al. Restricted immune re- sponses lead to CNS demyelination and axonal damage [J]. J Neuroimmunol, 2000,107(2) : 178-183.
  • 6Linker R A, Sendmer M, Gold R. Mechanisms of axonal degen- eration in EAE-lessons from CNTF and MHC I knockout mice [J]. J Neurol Sci, 2005,233(1-2) :167-172.
  • 7Mancardi G, Hart B A, Capello E, et al. Restricted immune re- sponses lead to CNS demyelination and axonal damage [J]. J Neuroimmunol, 2000,107(2) :178-183.
  • 8E I Behi M, Dubucquoi S, Lefranc D, et al. New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis [J]. Immunol Lett, 2005,96 (1) : 11-26.
  • 9Suvannavejh G C, Dal Canto M C, Matis L A, et al. Fas-media- ted apoptosis in clinical remission of relapsing experimental auto- immune encephalomyelitis [J]. J Clin Invest, 2000, 105 (2) 223-231.
  • 10Kountouras J, Zavos C, Chatzopoulos D. Apoptosis and autoim- munity as proposed pathogenetic links between Helicobacter pylo- ri infection and idiopathic achalasia[J]. Med Hypotheses, 2004, 63(4) : 624-629.

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国际神经病学神经外科学杂志
2011年 第5期

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