摘要
目的评价咪唑安定在新生儿机械通气中的镇静作用。方法选择2008年6月-2010年10月我科NICU收住的需机械通气危重新生儿58例,随机分为咪唑安定组30例和苯巴比妥组28例。观察2组用药期间心率、呼吸、血压、经皮氧饱和度(SpO2)和血气分析。结果咪唑安定组达到理想镇静率高于苯巴比妥组,差异有统计学意义(P<0.05)。咪唑安定组达到理想镇静后心率、SpO2、血pH、氧分压(PaO2)、二氧化碳分压(PaCO2)均较苯巴比妥组明显改善,差异均有统计学意义(P<0.01,P<0.05),2组呼吸和收缩压比较差异无统计学意义(P>0.05)。咪唑安定组烦燥脱管发生率低于苯巴比妥组,差异有统计学意义(P<0.05);2组呼吸机相关性肺炎、喉及声门损伤、气胸的发生率比较差异无统计学意义(P>0.05)。结论咪唑安定在新生儿机械通气中具有良好的镇静作用,无明显不良反应,值得推广应用。
Objective To evaluate the Midazolam＇s sedation in the neonatal mechanical ventilation. Methods 58 critically ill newborns were admitted to our NICU who needed mechanical ventilation from June 2008 to October 2010, and they were randomly divided in to midazolam group （ n = 30 ） and phenobarbital group （ n = 28 ）. The heart rate, respiration, blood pressure, transeutaneous oxygen saturation and blood gas analysis values of the two groups were compared during the treat- ments. Results Ideal sedative rate in Midazolam group was higher than that in phenobarbital group, and the difference was statistically significant （ P 〈 0.05 ）. Compared with Phenobarbital group, the heart rate, transeutaneous oxygen saturation, blood pH, PaO2 and PaCO2 improved in midazolam group after having achieved the desired sedation, and the differences between the two groups were statistically significant（P 〈0.01 ,P 〈 0.05 ）. There were no significant difference in respiratory and systolic blood pressure between the two groups（ P 〉 0.05 ）. irritability detach rate due to Irritability in Midazolam group was lower than that in phenobarbital group, and the difference was statistically significant（P 〈0.05） ;there were no significant differences in incident rates of ventilator-associated pneumonia, laryngeal and supraglottic injury and pneumothorax between the two groups （ P 〉 0.05）. Conclusion Midazolam in neonatal mechanical ventilation has a good sedative effect and with no significant adverse reactions. It should be widely applied.
出处
《临床合理用药杂志》
2011年第22期18-20,共3页
Chinese Journal of Clinical Rational Drug Use
