摘要
再狭窄严重制约了经皮冠状动脉介入治疗的远期疗效。其病理基础是新生内膜的形成;而血管平滑肌细胞增殖和迁移则是其主要成因。PTEN是至今发现的第一个具有磷酸酶活性的抑癌基因。对细胞的生长、增殖、分化、凋亡、黏附、迁移和血管生长等许多生物学行为有重要影响。近年来,对PTEN的研究逐渐从肿瘤领域延伸到一些非肿瘤领域中,随着研究的深入,人们发现其在再狭窄、心肌肥大、高血压、动脉粥样硬化中也发挥重要的作用。
It is found that the final effect of angioplasty is significantly limited by the high rate of restenosis,which is based on the abnormal proliferation and migration of vascular smooth muscle cells.PTEN is a new tumor suppressor gene discovered in recent years,which is also the first tumor suppressor gene with phosphatase activity found so far,having an important impact on cell growth,proliferation and differentiation,apoptosis,adhesion,migration and blood vessel growth,and many other biological behaviors.Along with the deepening of the study,researchers found it also played an important role in the non-neoplastic diseases,such as restenosis,cardiac hypertrophy,hypertension,and atherosclerosis,etc..
出处
《医学综述》
2011年第22期3392-3395,共4页
Medical Recapitulate
