摘要
花生四烯酸（arachidonic acid,AA）是一种人体内含量最丰富、性质最活跃、分布最广泛的多不饱和必需脂肪酸,具有很强的生物活性,其代谢网络是炎症代谢网络的重要组成部分。AA不仅在炎症中发挥重要作用而且与氧化应激关系密切。对两者相互作用的研究能够更好地阐明疾病发生的机制,
Arachidonic acid is an essential polyunsaturated fatty acid,and has strong biological activity.The metabolic network of arachidonic acid is an important part of inflammatory metabolic pathways.In recent years,more and more research findings show that arachidonic acid not only plays an important role in the inflammation but also has a close relationship with oxidative stress.Arachidonic acid both induces and inhibits oxidative stress.Oxidative stress also regulates the metabolism of arachidonic acid.Oxidative stress is a negative effector of free radicals which participates in organism aging as well as the pathogenesis and development of many diseases.The studies of the interrelationship between the two can make an organic combination of the inflammation and oxidative stress,better clarify disease mechanism,and facilitate the diagnosis and the treatment.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第11期2233-2236,共4页
Chinese Journal of Pathophysiology
基金
河北医科大学第二医院院级课题资助项目(No.2h0200918)
关键词
花生四烯酸
氧化性应激
炎症
Arachidonic acid
Oxidative stress
Inflammation
