摘要
目的：观察新发高血压患者的颈动脉内中膜厚度（IMT）及动脉硬化情况。方法：采用格式化调查表收集仪征市社区人群中477例新发高血压患者的信息,并检测其血糖、血脂、颈动脉IMT、C反应蛋白（CRP）等指标。结果：477例新发高血压患者的平均颈动脉IMT为（0.87±0.20）mm,动脉硬化斑块发生率为16.8%,平均CRP为0.70 mg/L（0.01~26.80 mg/L）。调整年龄和性别因素后,高CRP组（CRP≥3.0 mg/L）患者的动脉硬化斑块发生率、吸烟率、糖尿病患病率均高于CRP〈3.0 mg/L组（P〈0.05）。随着心血管疾病的累积风险增加,患者的IMT持续增厚、高CRP的发生率持续增高（P〈0.05）。结论：新发高血压患者中已存在一定程度的动脉硬化,高CRP者的颈动脉硬化斑块发生率升高,而颈动脉IMT、高CRP发生率随着患者心血管疾病风险因素累积的增多而逐渐增高。
Objective To study the carotid artery intima-media thickness and status of arteriosclerosis in newly diagnosed hypertensive patients.Methods A total of 477 newly diagnosed hypertensive patients in Yizheng community were enrolled.All these patients were surveyed by formatted questionnaire,and levels of blood sugar,blood lipids,C-reactive protein（CRP）and intima-media thickness（IMT）were determined.Results The mean value of IMT in 477 newly diagnosed hypertensive patients was（0.87±0.20） mm;plaque was found in 80 patients,with an incidence of 16.8%.CRP was 0.70 mg/L（0.01-26.80 mg/L）.After adjusting the factors of age and sex,incidence of sclerosis plaque,smoking habit and prevalence of diabetes,were significantly higher in CRP≥3.0 mg/L group（P0.05）.Accumulated risk of cardiovascular disease increased with the increase of IMT and high level of CRP（P0.05）.Conclusions Newly diagnosed hypertensive patients already have a certain degree of atherosclerosis,and newly diagnosed hypertensive patients with accumulated cardiovascular risk factors have higher CRP and thicker IMT.
出处
《诊断学理论与实践》
2011年第5期471-474,共4页
Journal of Diagnostics Concepts & Practice
基金
扬州市社会发展基金资助项目(YZ2007055)
关键词
颈动脉内中膜厚度
C反应蛋白
动脉硬化
高血压
Carotid artery intima-media thickness
C-reactive protein
Atherosclerosis
Hypertension
