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Electrophysiologic Effects of Propafenone on Action Potential of Neonatal and Adult Purkinje Fibers

Electrophysiologic Effects of Propafenone on Action Potential of Neonatal and Adult Purkinje Fibers
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摘要 The electrophysiological effects of 5.8×10<sup>-6</sup> mol/L propafenonewere studied in neonatal canine Purkinje fiber compared with changes in theadult canine. The method used was microelectrode technique. This study sug-gests that Purkinje fibers are less sensitive to propafenone in the neonate than inthe adult, but at shorter ample lengths, the difference between them is not sig-nificant. The electrophysiological effects of 5.8×10^(-6) mol/L propafenonewere studied in neonatal canine Purkinje fiber compared with changes in theadult canine. The method used was microelectrode technique. This study sug-gests that Purkinje fibers are less sensitive to propafenone in the neonate than inthe adult, but at shorter ample lengths, the difference between them is not sig-nificant.
出处 《中国医科大学学报》 CAS CSCD 1991年第S2期37-42,共6页 Journal of China Medical University
关键词 PROPAFENONE action POTENTIAL PURKINJE fibers propafenone action potential Purkinje fibers
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