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荷兰结核病在不同年龄人群间的传染:应用DNA指纹法的分析 被引量:2

Transmission of tuberculosis between people of different ages in The Netherlands: an analysis using DNA fingerprinting
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摘要 背景:1950年至1980年间荷兰结核病感染率的下降比发病率的下降快得多。本研究的目的在于确定这一现象是否能用年龄组内的不同传播所解释。方法:应用RFLP法将荷兰1993~1996年所有菌株进行分型,同一指印的菌株被鉴定为同一来源,由此确定2个荷兰患者年龄上的相关性。结果:两簇人群81对菌株患者年龄的平均差异是13.9岁。而所有可能配对患者资料的年龄平均差异是25.5岁。Fisher氏检验相关系数为0.62 (95%可信区间[CI]值为0.46~0.74)。结论:结核病传染源更易传染给和他们年龄相近的人群。由于在1950~1980年间,病例的平均年龄在增加。传染源可能对过去常观测年感染率的儿童的感染更少。在低结核国家中儿童、青少年结核病的年感染率的资料不适于该人群中的老年者。
出处 《国际结核病与肺部疾病杂志》 2000年第1期35-39,共5页 The International Journal of Tuberculosis and Lung Disease
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