摘要
目的观察苦参碱联合化疗治疗晚期非小细胞肺癌患者的近期疗效、生活质量和不良反应。方法将80例非小细胞肺癌患者采用随机数字表的方法分为观察组和对照组各40例,对照组给予长春瑞滨和顺铂化疗,观察组在此基础上加用苦参碱,观察两组患者近期疗效、生活质量和不良反应。结果观察组近期总有效率、生活质量和不良反应均好于对照组,差异有统计学意义(P<0.05)。结论苦参碱联合化疗治疗晚期非小细胞肺癌,可获得较好的近期疗效,提高生活质量,不良反应可耐受,值得临床推广应用。
Objective To evaluate the short-time effect,quality of life and adverse reaction of matrine combined chemotherapy in the treatment of patients with advanced non-small cell lung cancer（NSCLC）.Methods 80 patients with advanced NSCLC were divided randomly into the intervention group（40 cases） and the control group（40 cases）.All patients received chemotherapy with vinorelbine and cisplatin,and the patients in the intervention group in addition had the use of matrine.The short time effects,quality of life and adverse reaction were observed and compared between the groups.Results The total effective rate,quality of life and adverse reaction of the investigation group were better than that of the control group： P0.05.Conclusion Matrine combined chemotherapy in the treatment of patients with advanced non-small cell lung cancer is effective and safe.It improves quality of life and hence is worthy of being recommended for a wider use in clinical practice.
出处
《临床肺科杂志》
2011年第12期1906-1907,共2页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
晚期
化学治疗
苦参碱
non-small cell lung cancer
advanced
chemotherapy
matrine
