摘要
目的探讨抑癌基因（P16）、凋亡抑制因子（survivin）在口腔扁平苔藓（OLP）、口腔鳞状细胞癌（OSCC）中的表达意义及关系。方法采用免疫组化S—P法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织P16、survivin基因的表达，并分析其相关性。结果P16蛋白、survivin蛋白在正常口腔黏膜组织、0s—CC组织和糜烂型OLP组织中的表达比较差异均有统计学意义（P〈0．05）。P16蛋白与survivin蛋白在三种组织中的表达呈正相关。结论P16、survivin与OLP向OSCC转变有关，它们在OSCC的发生发展中起重要作用。
Objective To study the expression and clinical significance of P16, a novel member of anti - oncogene protein family, and survivin, a novel member of inhibitor of apoptosis protein family, in oral lichen planus and oral squamous cell carcinoma. Methods Immunohistochemical technique S - P was used to detect the expression of P16 and survivin protein in 40 cases of OSCC, 40 cases of OLP tissues and 26 cases of normal oral mueosa, and their clinical significance was analyzed. Results The expression of P16 and survivin were significantly different in normal oral mucosa, OLP and OSCC tissues （P 〈 0.05 ）. The expressions of survivin and P16 showed a positive correlation in three types of tissues. Conclusions P16 gene and survivin gene involve in the transformation of OLP toOSCC. P16 gene and survivin gene are important in the development and progress of OSCC.
出处
《中国实用医刊》
2011年第22期45-47,共3页
Chinese Journal of Practical Medicine
