摘要
目的:探讨食管癌放射治疗的疗效及其影响预后的相关因素.方法:收集2004-04/2009-04采用非手术综合治疗的食管癌患者85例进行预后分析,探讨影响预后的临床因素.生存率采用Kaplan-Meier法进行计算,并采用对数秩和检验(Log-rank test法)进行单因素分析,采用Cox比例风险模型对可能影响其预后的因素进行多因素回归分析.结果:随访率100%,1、3年生存率分别为65.9%、29.4%.单因素分析影响食管癌预后的因素有年龄、病变部位、病变长度、临床分期、治疗方式、放疗技术和近期疗效,而性别、放疗剂量大小与预后无关.Cox比例风险回归模型进行多因素分析显示治疗方式、临床分期和近期疗效为影响预后的独立因素.结论:食管癌放疗后总体生存率仍然较低,治疗方式、临床分期和近期疗效是影响食管癌预后的主要因素.
AIM： To investigate the efficacy of radiotherapy for esophageal carcinoma and to analyze prog- nostic factors for esophageal carcinoma after radiotherapy. METHODS： Eighty-five patients with esopha- geal carcinoma who underwent comprehensive non-surgical treatment from April 2004 to April 2009 were enrolled in this study. Clinical factors influencing prognosis were evaluated. Survival was analyzed by Kaplan-Meier method. Univar- iate analysis was completed by using log-rank test （Log-rank test method）, and multivariate analysis was performed using Cox proportional hazards regression model. RESULTS： The follow-up rate was 100%. The 1- and 3-year survival rates were 65.9% and 29.4%, respectively. Univariate analysis showed that age, tumor site, lesion length, clinical stage,treatment mode, radiation techniques, and shortterm effect were prognostic factors for esophageal carcinoma. Multivariate Cox regression analysis revealed that treatment mode, clinical stage and short-term effect were independent prognostic factors. CONCLUSION： The long-term survival of patients with esophageal carcinoma after radio- therapy is poor. Treatment mode, clinical stage and short-term effect are main factors affecting the prognosis of esophageal carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第26期2772-2776,共5页
World Chinese Journal of Digestology
关键词
食管肿瘤
放射治疗
单因素分析
COX比例风险回归模型
预后分析
Esophageal carcinoma
Radiotherapy
Univariate analysis
Cox proportional hazards regression model
Prognostic analysis
