摘要
目的探讨肿瘤组织中HER2-neu表达与胃癌预后的相关性。方法计算机检索相关文献,运用Meta分析方法对纳入文献进行综合定量分析。计算合并相对危险比(HR)和95%可信区间(95%CI)。结果入选文献20篇,包括患者总数为4 398例。有单因素分析结果的文献16篇,一致性检验Q值为27.48(P=0.025),合并HR为1.57(95%CI1.30～1.90);合并多因素分析结果的文献5篇,一致性检验Q值为4.03(P=0.401),合并HR为1.30(95%CI 1.09～1.52)。结论 HER2-neu是胃癌预后不良的一个生物标志物。
Objective To evaluate the prognostic significance of HER2-neu overexpression in gastric cancer. Methods Investigations between HER2-neu status and survival were identified by published studies. Pooled hazard ratio （HR） and its 95% confidence interval （95%CI） were calculated to evaluate the risk of disease. Results A total of 20 studies were analyzed by Meta-analysis method, including cumulative 4 398 cases. Pooling data from 16 studies of univariate analysis showed worse survival of patients with HER2-neu（ ＋ ） （pooled HR= 1.57, 95~CI 1.30~ 1.90）, and maintained in 5 studies of multivariate analysis（pooled HR= 1.30, 95%CI 1. （t941.52）. The analysis for heterogeneity（Q statistic test） for 16 studies of univariate analysis showed they had heterogeneity（Q = 27.48, P = 0. 025）, but for 5 studies of multivariate analysis showed little heterogeneity（Q = 4. 03, P = 0. 401 ）. Conclusion HER2 neu overex pression is a worse and independent parameter for overall survival of gastric cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第10期1173-1177,共5页
Cancer Research on Prevention and Treatment
