摘要
应用简易的邻苯三酚自氧化测定SOD1活性的方法,测定了两个XP家系成员23人和141名正常人的全血SOD1活性,结果表明,XP患者全血SOD 1活性与阿龄对照组相比,差异显著(P<0.06);杂合子全血SOD 1活性与同龄对照组相比,无显著差异(P>0.05)。
SOD1 activity in patients and members of two families with xeroderma pigmentosum (XP) and 141 healthy adults of control group were measured with a modified method of pyrogallol airtoxidation. The result showed a significant difference (P<0.05) between the XP patients' SOD1 activity (1 114.29±79.95u/gHb) and the activity of age-matched centrols (1 532.91±31.01), but no significant difference (P>0.05) was noted between the heterzygotes SOD1 activity (1 224.90±63.62u/gHb) and the activity of age-matched controls (1 341.67±79.95u/gHb). It suggested:(1) the pathogenesis of Xp might be related not only with the defect of DNA repair but with SOD1 activity insufficincy as well; (2) some gene loci related with DNA repair might be linked with SOD1 gene on chromosome 21.
出处
《遗传与疾病》
CSCD
北大核心
1990年第2期83-85,128,共3页
关键词
着色性干皮病
超氧物歧化酶
杂合子
Superoxide dismutase Xero derma pigmentosum Heterozygotes
