摘要
目的:探讨高血压患者血清C-反应蛋白(CRP)水平变化与预后的关系。方法:40例伴随不同程度动脉硬化的原发性高血压患者分别进行颈动脉粥样硬化检测及血清CRP测定,对测定结果进行统计学分析。结果:40例高血压患者中颈动脉粥样硬化者28例,无颈动脉粥样硬化者12例;同时颈动脉粥样硬化者的血清CRP平均水平明显高于无颈动脉粥样硬化者(t=6.232,P<0.05)。而在颈动脉粥样硬化者中,有颈动脉斑块的患者血清CRP显著高于颈动脉内膜(IMT)增厚患者(t=4.362,P<0.05)。治疗后,所有患者的CRP与治疗前比较均有明显改善,差异有统计学意义(P<0.05)。结论:高血压患者的CRP水平有助于动态评价病情变化和判断临床预后,可作为高血压患者预后不佳发生的重要预测指标,值得临床推广应用。
Objective： To discuss the relaiton of C-reactive protein （CRP） levels and prognosis in hypertensive patients. Methods： 40 patients with different degrees of atherosclerosis with essential hypertension were respectively detected carotid atherosclerosis and serum CRP. Results： Accorded the ultrasound results, 28 cases of carotid artery atherosclerosis and 12 cases without carotid artery atherosclerosis in the 40 cases of hypertension, the former＇s average level of serum CRP was significantly higher than the latter （t=6.232, P〈0.95）. In the carotid atheroselerosis, patients of carotid artery plaque with serum CRP was significantly higher than in patients with thickened IMT （t=4.362, P〈0.05）. After treatment, CRP of all patients were significantly improved, the difference was statistically significant （P〈0.05）. Conclusion： CRP levels in patients with high blood pressure can help dynamic evaluate of the disease changes and determine the clinical outcome, it can oc- cur as an important prognostic predictor of poor, it is worthy of clinical application.
出处
《中国医药导报》
CAS
2011年第32期173-174,共2页
China Medical Herald
关键词
高血压
动脉硬化
C反应蛋白
预后
Hypertension
Atherosclerosis
C-reactive protein
Prognosis
