摘要
本文报道采用电泳技术对北京、上海、长春3市的4个中国昆明小鼠(简称KM)实验群体中24个蛋白质标志研究的结果,与我国1981年从美国引进的NIH小鼠进行比较,显示出:(1)KM小鼠亚群间等位基因组成无明显差异,它们间遗传距离为0.008—0.027,与群体封闭时间成正相关;(2)4个KM小鼠群体间聚类分析发现S:KM群体为特殊一类,该结果与KM亚群间下颌骨分析结果相符;(3)KM与Swiss来源的NIH小鼠群体间在E(?)-3、Es-10、Got-2、Glo-1、Gpt-1、和Mpi-1座位上的等位基因组成存在显著差异,它们之间的遗传距离平均值为0.131±0.011,证实中国KM小鼠为非Swiss来源的一个亚种。
This paper presents the results of study on 24 protein markers by means of electrophoresis in 4 KM subcolonies maintained in Beijing, Shanghai and Changcun, and compares it with that of one NIH colony introduced from U.S.A. in 1982. The results revealed that: (1) There were few genetic variants on allelic constitutions of Chinese KM mouse colonies, and the genetic distance among KM subcolonies is 0.008-0.027 positively related with the time the colony closed; (2) The unique position of S: KM mouse was shown in phylogenetic diagram of 4 KM subcolonies, which agrees with the result from mandible analysis; (3) The allelic constitutions of KM mice differs from NIH mice a Swiss derivative colony at Es-3, Es-10, Glo-1, Gpt-1, Got-2 and Mpi-1 loci and the average genetic distance between KM and NIH colonies is 0.131 + 0.011, which indicates that Chinese KM mice is one of non-Swiss derivative subspecies.
基金
国家自然科学基金(0387018)
关键词
小鼠
蛋白质多态性
群体遗传
Mouse, Protein polymorphism, Population genetic
