摘要
目的:制备丹皮酚-β-环糊精包合物(Pae-β-CYD)的结肠定位释药片剂。方法:以Pae-β-CYD,果胶,乙酸钙作为片芯,Eudragit S100乙醇溶液包衣,考察包衣增重、增塑剂用量、熟化时间与温度等因素对包衣片体外释药的影响。结果:包衣增重为12%,增塑剂用量为20%时,熟化温度为45℃,熟化时间为12 h,Pae-β-CYD片剂在果胶酶或大鼠结肠内容物中的释药时滞为5～6 h。结论:Pae-β-CYD结肠定位释药片剂显示pH环境和酶降解依赖释药特征。
Objective： To prepare paeonol-β-cyelodextrin inclusion complex （Pae-fl-CYD） loaded colon-specific release tablets. Method： The core tablets were prepared with the mixture of Pae-β-CYD inclusion compleX, pectin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro. Result： About 5-6 h retarded release of paeonol in the dissolution media of pecti- nase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate （DBP） was used as plasticizer, and subsequently curing the tablets at 45℃ for 12 h. Conclusion：Pae-β-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第21期2956-2959,共4页
China Journal of Chinese Materia Medica
基金
科技部国际科技合作项目(2009DFA31330)
国家"重大新药创制"科技重大专项(2009ZX09502-009)
