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微小RNA在免疫系统中作用机制的研究进展 被引量：3

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摘要 miR作为一类内源性短序列[约21—25核苷酸（nt）]非编码的RNA，作用于基因的转录后水平，通过与mRNA的3’端非翻译区的特异性结合达到间接抑制翻译或直接降解mRNA的目的，进而参与调控机体细胞的增殖、分化、代谢、凋亡等生物学活动^[1]。近年研究发现，在免疫系统中，
作者 秦保东 梁艳 杨再兴 仲人前
机构地区 第二军医大学附属长征医院实验诊断科 全军医学免疫诊断中心 全军临床免疫重点实验室
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2011年第10期953-956,共4页 Chinese Journal of Laboratory Medicine
关键词 微小RNA 免疫系统 mRNA 非翻译区 特异性结合 生物学活动 机体细胞 核苷酸
分类号 R392.1 [医药卫生—免疫学]
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参考文献42

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同被引文献28

  • 1Alton Etheridge,Inyoul Lee,Leroy Hood,David Galas,Kai Wang.Extracellular microRNA: A new source of biomarkers[J]. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis . 2011 (1)
  • 2Mariàngels de Planell-Saguer,María Celina Rodicio.Analytical aspects of microRNA in diagnostics: A review[J].Analytica Chimica Acta.2011(2)
  • 3Richard Hummel,Damian J. Hussey,Joerg Haier.MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types[J].European Journal of Cancer.2009(2)
  • 4RC Friedman,KK Farh,CB Burge,DP Bartel.Most mammalian mRNAs are conserved targets of microRNAs. Genome Research . 2009
  • 5Glen Reid,Michaela B. Kirschner,Nico van Zandwijk.Circulating microRNAs: Association with disease and potential use as biomarkers[J]. Critical Reviews in Oncology / Hematology . 2010 (2)
  • 6Victoria Furer,Jeffrey D. Greenberg,Mukundan Attur,Steven B. Abramson,Michael H. Pillinger.The role of microRNA in rheumatoid arthritis and other autoimmune diseases[J]. Clinical Immunology . 2010 (1)
  • 7Justin A. Bishop,Hila Benjamin,Hila Cholakh.Accurate Classification of Non-Small Cell Lung Carcinoma Using a Novel MicroRNA-Based Approach. Clinical Cancer Research . 2010
  • 8Keller Andreas,Leidinger Petra,Lange Julia,Borries Anne,Schroers Hannah,Scheffler Matthias,Lenhof Hans-Peter,Ruprecht Klemens,Meese Eckart.Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PloS one . 2009
  • 9Tijsen AJ,Creemers EE,Moerland PD, et al.MiR423-5p as a circulating biomarker for heartfailure. Circulation Research . 2010
  • 10刘蕊,孙凌云.微小RNA在自身免疫性疾病中的研究进展[J].中华风湿病学杂志,2011,15(2):124-127. 被引量：1

引证文献3

二级引证文献6

中华检验医学杂志
2011年 第10期

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