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有氧运动康复对慢性心力衰竭患者运动耐力的影响 被引量:32

Effects of aerobic exercise on exercise tolerance in patients with chronic heart failure
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摘要 目的探讨有氧运动康复对慢性心力衰竭患者运动耐力的影响。方法左心室射血分数(LVEF)〈49%的慢性心力衰竭患者50例,分为运动组25例及非运动组25例,并实施心肺运动试验(CPET)。运动组执行以无氧代谢阈值(AT)前10J/s为运动强度而制定的有氧运动处方,非运动组要求日常活动。先进行6次医院监护下的有氧运动训练,之后采用家庭有氧运动训练。3个月后复查CPET。结果两组患者无氧代谢阈值氧耗量(VO2AT)、峰值氧耗量、AT负荷、峰值负荷、峰值每搏摄氧量(峰值VO2/HR)、二氧化碳通气当量斜率(VE/VCO2斜率)基线水平差异均无统计学意义(均P〉0.05)。经过3个月有氧运动康复后,运动组VO2AT、峰值氧耗量、AT负荷、峰值负荷、峰值VO2/HR较基线增加,VE/VCO2斜率较基线减小,3个月前后,VO2AT、峰值氧耗量、AT负荷、峰值负荷、峰值VO2/HR、VE/VVO2斜率变化值分别以△VO2AT、△峰值氧耗量、△AT负荷、△峰值负荷、△峰值VO2/HR、△VE/VVO2斜率表示,两组患者△VO2AT、△峰值氧耗量、△AT负荷、△峰值负荷、△峰值VO2/HR差异均有统计学意义[运动组与非运动组分别为,△VO2AT:2.8(1.2~3.5)ml·kg^-1·min^-1,-0.3(-2.8-0.1)ml·kg^-1·min^-1,P〈0.01;△峰值氧耗量:3.4(1.8~4.6)ml·kg^-1·min^-1,-0.5(-1.4~0.3)ml·kg-1·min^-1,P〈0.01;△AT负苛:15.0(2.5—22.5)J/s,0.5(-4.2—3.8)J/s,P〈0.01;△峰值负荷:15.0(1.3~25.0)J/s,0.0(-8.8~15.0)J/s,P〈0.05;△峰值VO2/HR:2.3(0.0-4.0)ml·kg^-1·beat^-1,-0.1(-0.7~1.2)ml·kg^-1·beat^-1,P〈0.01],AVE/VCO2斜率差异无统计学意义[运动组与非运动组:-2.3(-12.2~1.8),1.0(-0.4~2.6),P〉0.05]。结论3个月的有氧运动康复可以改善慢性心力衰竭患者的运动耐力。 Objective To explore the effects of aerobic exercise on exercise tolerance in patients with chronic heart failure (CHF). Methods A total ofSO CHF patients with left ventricular ejection fraction (LVEF) 〈49% by echocardiography were enrolled. And they were randomly divided into exercise group ( n = 25 ) and non-exercise group ( n = 25 ). Cardiopulmonary exercise testing (CPET) was performed. The patients of exercise group underwent an aerobic exercise program in which exercise intensity was decided by anaerobic threshold (AT) before 10 J/s while those of non-exercise group performed daily activities. After 6 sessions of supervised aerobic exercise, the home-based aerobic exercise training began. CPET was reexamined 3 months later. Results The VO2 AT, VO2 peak, Load AT ,Load peak, peak VO2/HR and VE/ VCO2 slope at baseline were similar between exercise group and non-exercise group ( P 〉 0.05 ) . The VO2 AT, VO2 peak, Load AT , Load peak and peak VO2/HR in patients of exercise group were increased compared with baseline, The differences between baseline and 3 months later expressed as △VO2 AT, △VO2 peak, ALoad AT,ALoad peak , Apeak VO2/HR and △VE/VCO2 slope,The differences of △VO2 AT, △VO2 peak, △Load AT, △Load peak and Apeak VO2/HR between two groups were statistically significant [ △VO2 AT: 2.8(1.2-3.5)ml · kg^-1 . min^-1 vs -0.3( -2.8-0. 1)ml · kg^-1 . min^-1,P 〈0.01; △VO2peak:3.4(1.8-d.6)ml · kg^-1 . min^-1 vs -0.5(-1.4-0.3) ml · kg^-1 . min^-1,P〈0.01; ALoad AT:15.0(2. 5 -22.5) J/s vs 0.5( -4.2 -3.8) J/s,P 〈0.01; △Load peak: 15.0(1.3 -25.0) J/s vs0.0 ( -8.8-15.0) J/s,P〈0. 05; △peak VO//HR : 2.3(0.0-4.0)ml · kg^-1 . min^-1 beat^-1 vs -0. 1 ( - 0. 7 - 1.2) ml · kg^-1 · beat^-1, P 〈 0. 01 ]. The difference of AVE/VCO2 slope was not statistically significant [ -2.3( -12.2-1.8)vs 1.0( - 0. d - 2.6) ,P 〉 0.05]. Conclusion After 3 months of aerobic exercise, exercise capacity may improve in the CHF patients.
出处 《中华医学杂志》 CAS CSCD 北大核心 2011年第38期2678-2682,共5页 National Medical Journal of China
基金 基金项目:上海市重大科技攻关基金(05DZ19505) 上海市市级医院新兴前沿技术联合攻关项目(SHDC12010117)
关键词 心力衰竭 充血性 运动耐量 有氧运动 心肺运动试验 Heart failure, congestive Exercise tolerance Aerobic exercise Cardiopulmonary exercise test
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参考文献18

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