摘要
不断增长的临床资料表明，影响昼夜节律的现代生活方式增加肥胖和糖尿病的发病风险。最近的遗传性动物模型也进一步证实了昼夜节律与代谢之间的密切相关。昼夜节律生物钟不仅仅存在于中枢神经系统，还存在于机体几乎所有细胞，形成不同层次的昼夜节律系统。分子生物钟通过长期的进化，以使机体能够预见和准备适应环境的每天变化，通过驱动基因表达和酶的活性调控细胞和组织功能。目前在这一领域的基础科学以惊人的速度向前发展，有望不断揭示昼夜节律钟与代谢之间联系的机制，这对于理解糖尿病和肥胖等代谢性疾病的生理和病理机制都有重要意义，并为其防治提供理论基础。
Increasing clinical evidence shows that modern lifestyle interrupting circadian rhythm contributes to the prevalence of obesity and diabetes. Recent genetic animal models further support the interaction of circadian rhythms and metabolic state. Circadian clock is not limited to be in central nervous system, and is also present in nearly all cells of the body, which constitute hierarchically circadian systems. The molecular circadian clock is evolved to allow organisms to anticipate and prepared for predictable, daily changes in the environment and regulates cellular and tissue function by driving patterns of gene expression and enzymatic activity. At present, basic science in this field has progressed at an extraordinary pace and is expected to continue unraveling the mechanisms linking circadian clocks to metabolism, which is important for understanding the pathophysiology of metabolic diseases such as obesity and diabetes, and provides a conceotual basis for the orevention and therapeutics of these diseases.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2011年第10期793-795,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
昼夜节律
肥胖症
糖尿病
换班工作
Circadian rhythms
Obesity
Diabetes mellitus
Shift work
