摘要
目的探讨联合检测血清癌胚抗原(CEA)、糖蛋白抗原199(CA199)、糖蛋白抗原72-4(CA72-4)、胃蛋白酶原及其亚群PG(PG-Ⅰ、PG-Ⅰ/PG-Ⅱ)对胃癌诊断的临床价值。方法采用化学发光微粒子免疫检测方法测定75例胃癌患者、75例良性胃病患者以及30例健康人血清中CEA、CA199、CA72-4和PG(PG-Ⅰ、PG-Ⅰ/PG-Ⅱ)的水平,比较三组间的差异。结果胃癌患者血清中各标志物检测水平和阳性率与良性胃病组及对照组比较差异有统计学意义(P<0.01)。5项标志物联合检测的敏感性为85.8%,与单项检测相比差异有统计学意义(P<0.01)。结论 CEA、CA199、CA72-4、PG-Ⅰ、PG-Ⅰ/PG-Ⅱ对胃癌具有较高的辅助诊断价值,其联合检测有助于提高胃癌诊断的敏感性。
Objective To evaluate the diagnostic value of combined detection of serum CEA,CA199,CA72-4,PG-Ⅰ and PG-Ⅰ/PG-Ⅱ for gastric carcinoma.Methods 75 patients with gastric carcinoma（group A）,75 patients with benign gastric diseases（group B） and 30 healthy individuals（group C） were measured for the levels of serum CEA,CA199,CA72-4,PG-Ⅰ and PG-Ⅰ/PG-Ⅱ,through chemiluminescent microparticle immunoassay.The obtained data were compared between the three groups.Results The positive rate and serum levels of five tumor markers（CEA,CA199,CA72-4,PG-Ⅰ and PG-Ⅰ/PG-Ⅱ） in group A were significantly different from those in group B and group C（P〈0.01）.Moreover,the sensitivity of the combined detections of the five tumor markers（85.8%） were significantly higher than that of the respective detection（P〈0.01）.Conclusion The levels of serum CEA,CA199,CA72-4,PG-Ⅰ and PG-Ⅰ/PG-Ⅱ are very valuable in the diagnosis of gastric carcinoma.The combined detection of the five tumor markers can promote the sensitivity for the diagnosis of gastric carcinoma.
出处
《海南医学》
CAS
2011年第21期105-107,共3页
Hainan Medical Journal
关键词
肿瘤标志物
胃蛋白酶原
胃癌
Tumor markers
Pepsinogens
Gastric carcinoma
