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新型2-(2,2,3,3-四甲基环丙基)噁唑啉的合成

Synthesis of Novel 2-(2,2,3,3-Tetramethylcyclopropyl)oxazolines
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摘要 2,2,3,3-四甲基环丙烷甲酸和手性氨基醇经酰化反应制得6个N-β-羟基烷基酰胺(3a～3f)。以DDQ/PPh3为羟基活化剂,3a～3f经分子内脱水环合合成了6个2-(2,2,3,3-四甲基环丙基)噁唑啉,其结构经1 H NMR,13 C NMR,IR和HR-MS表征(其中5个为新化合物)。 Six 2-（2,2,3,3-tetramethylcyclopropyl）oxazolines（five of them were new compounds） were synthesized by intramolecular cyclic dehydration reaction of N-β-hydroxyl-alkyl amides,which were prepared by acylation of 2,2,3,3-tetramethylcyclopropylcarboxylic acid with chiral amino alcohols.The structures were characterized by 1H NMR,13C NMR,IR and HR-MS.
作者 徐全才 姜岚 李争宁
机构地区 大连大学环境与化学工程学院 大连大学辽宁省生物有机化学重点实验室
出处 《合成化学》 CAS CSCD 北大核心 2011年第6期750-753,共4页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20672016)
关键词 噁唑啉 三苯基膦 DDQ 环丙烷甲酸 合成 oxazoline triphenylphosphine DDQ cyclopropylcarboxylic acid synthesis
分类号 O626 [理学—有机化学]
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合成化学
2011年 第6期

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