摘要
目的探讨持续性心房纤颤（房颤）患者血中D-二聚体水平的变化及其临床意义。方法持续性房颤患者39例，根据超声检查结果分为血栓阳性（22例）和血栓阴性（17例）组，另选窦性心律患者（窦律组）和正常对照组各20例。所有对象均用酶联免疫吸附双抗体夹心法（ELISA）测定血中D-二聚体水平。结果血栓阳性和阴性组D-二聚体水平均高于窦律组和正常对照组（P均〈0．05），血栓阳性组D-二聚体水平高于血栓阴性组[（0．70±0．10）mg／L vs（0．41±0．18）mg／L，P〈0．05]。结论D-二聚体水平增高是持续性房颤患者左房血栓形成的重要预测因子。
Objective To investigate the variations of D - dimer level and its clinical significance in patients with persistent atrial fibrillation （AF）. Methods 39 patients with persistent AF were divided into thrmnbosis - positive group （ n = 22） and thrombosis - negative group （ n = 17） based on the results of transthoracic and transesophageal echocardiography. In parallel, 20 patients with various heart diseases and sinus rhythm （ sinus rhythm group） and 20 healthy subjects （ normal control group） were also included in this study. The whole blood D - dimer levels in each group were deter- mined by enzyme linked immunosorbent assay （ELISA）. Results The D - dimer levels were higher in both thrombosis - positive group and thrombosis - negative group than in sinus rhythm group and normal control group （ all P 〈 0.05 ） , The D - dimer levels were higher in thrombosis - positive group than in thrombosis - negative group [ （0.70 ± 0.10） μg/ ml vs. （0.41 ± 0.18 ）μg/ml, P 〈 0.05 ]. Conclusion The increasing level of D - dixner is an important predictable factor for left atrial thrombosis in patients with atrial fibrillation.
出处
《徐州医学院学报》
CAS
2011年第7期470-472,共3页
Acta Academiae Medicinae Xuzhou
关键词
心房纤颤
血栓
D-二聚体
atrial fibrillation
thrombosis
D - dimer
