摘要
目的研究2-溴-4-氟吡啶的合成工艺，并对其毒理活性进行研究。方法以2-溴吡啶为起始原料经过四步反应以克级规模合成了2-溴-4-氟吡啶；以昆明种小鼠为研究埘象，采用改进寇氏法测定了该化合物经腹腔注射后对小鼠的急性毒性测试。结果2-溴-4-氟吡啶24hLD50值为0．507g／kg，95％可信区间为0．451～0．571g／kg。结论2-溴-4-氟吡啶属于中等毒性化合物。
Objectives To investigate the synthetic techniques of 2 - bromo - 4 - fluoropyridine and its toxicity on Kunming （KM） mice. Methods 22 - bromo - 4 - fluoropyridine was synthesized in grams - scale using 2 - bromopyridine as starting material through the four - step reactions. Following intraperitoneal injection into KM mice, the acute toxicity was studied and determined by the improved Karber＇s method. Results The title compound could lead to death in some mice, with the median lethal dose （LD50） of 0. 507 g/kg in mice at 24 h and 95% reliable limit range of 0.451 - 0.571 g/kg. Conclusion 2 -Bromo- 4 -fluoropyridinc is a moderately toxic compound.
出处
《徐州医学院学报》
CAS
2011年第7期449-451,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省高校自然科学基金（10KJB150018）
徐州医学院院长专项基金（2010KJZ27）
2010年江苏省大学生创新项目（778）
