摘要
在肿瘤疫苗中树突状细胞(DC)是启动抗肿瘤免疫的主要辅助细胞。细胞因子信号抑制因子1(SOCSI)对细胞因子信号转导具有抑制作用。最近的研究表明,抑制DC中SOCS1的功能对提高肿瘤疫苗的抗肿瘤活性具有重要作用,并且在如何抑制其功能的方法上也取得了重大进展。
Dendritic cells (DCs) are the important auxiliary cells in tumor vaccines to activate antitumor immunity. Suppressor of cytokine signaling 1 ( SOCS1 ) has been shown to play an important role in inhibition of cytokine signal transduction. Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity, and in the methods of restraining SOCS1 's function have also made significant progress.
出处
《国际肿瘤学杂志》
CAS
2011年第10期729-732,共4页
Journal of International Oncology
基金
福建省自然科学基金贤助项目(2010D013)