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细胞因子信号抑制因子1在树突状细胞肿瘤疫苗中的作用 被引量:3

Function of suppressors of cytokine signaling 1 in dendritic cells-based tumor vaccines
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摘要 在肿瘤疫苗中树突状细胞(DC)是启动抗肿瘤免疫的主要辅助细胞。细胞因子信号抑制因子1(SOCSI)对细胞因子信号转导具有抑制作用。最近的研究表明,抑制DC中SOCS1的功能对提高肿瘤疫苗的抗肿瘤活性具有重要作用,并且在如何抑制其功能的方法上也取得了重大进展。 Dendritic cells (DCs) are the important auxiliary cells in tumor vaccines to activate antitumor immunity. Suppressor of cytokine signaling 1 ( SOCS1 ) has been shown to play an important role in inhibition of cytokine signal transduction. Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity, and in the methods of restraining SOCS1 's function have also made significant progress.
出处 《国际肿瘤学杂志》 CAS 2011年第10期729-732,共4页 Journal of International Oncology
基金 福建省自然科学基金贤助项目(2010D013)
关键词 树突细胞 癌症疫苗 SOCS1 Dendritic cells Cancer vaccines SOCS1
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