摘要
整合素作为黏附分子中的一大类家族,广泛的参与机体的各种病理生理活动,包括细胞生存、生长、分化、迁移、炎症反应、血小板聚集、组织修复以及肿瘤侵袭转移等多个过程.自整合素发现20多年来,已有许多整合素介导的靶向药物相继应用于临床,而且每年有更多新的药物进行临床试验,其中有些药物显示出广阔的临床应用前景.此外,基于整合素在肿瘤细胞中的特殊病理作用,以及作为细胞膜表面药物的可及性和成药性,使其逐渐成为肿瘤靶向药物治疗中的研究热点.正因如此,探索整合素在胃癌的中作用可为胃癌的分子靶向治疗提供潜在的理论基础.本文就整合素在胃癌侵袭转移及靶向药物治疗中的相关研究进展作一综述.
Integrins are a large family of cell adhesion molecules that are involved in many important cellular and pathological functions including cell survival,growth,differentiation,migration,inflammatory responses,platelet aggregation,tissue repair and tumor invasion.Over the past two decades,several integrin-targeted drugs have made their way into clinical practice,many others are increasing each year in clinical trials and still more are showing promising potential for therapeutic development based on preclinical studies.Additionally,the role of integrins in pathological conditions combined with their druggability by means of cell surface accessibility makes them attractive pharmacological targets in cancer research.As such,the identification of key roles of integrins in gastric cancer has revealed their substantial potential as therapeutic targets.This review summarizes recent progress in the study of correlation betweenintegrins and invasion and metastasis of gastric cancer and evaluates their values in developing molecularly targeted therapies for this disease.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第24期2540-2545,共6页
World Chinese Journal of Digestology
关键词
整合素
胃癌
分子靶向治疗
侵袭
转移
Integrins
Gastric cancer
Molecularly targeted therapy
Invasion
Metastasis
