摘要
目的探讨苯磺酸左旋氨氯地平联合单硝酸异山梨酯治疗高血压患者伴有冠心病的临床效果.方法将30例老年高血压伴有冠心病患者随机分为治疗组,对照组各15例,两组均给予苯磺酸左旋氨氯地平2.5 mg/d治疗,治疗组联合单硝酸异山梨酯60 mg/d治疗,连用24周.结果两组的病人血压均显著下降(P<0.05),其中治疗组对血压的改善更优于对照组.结论 ISMN-SR在有效降低SBP的同时降低DBP不明显,使PP减小,有利于老年ISH患者的降压治疗;单用钙离子拮抗剂血压控制仍不理想的老年ISH患者加用硝酸酯类是比较理想的联合用药.
Objective To observe the clinical effect of combination of isosorbide mononitrate and levamlodipine on hypertension accompanied by coronary heart disease.Methods 30 patients with hypertension accompanied by coronary heart disease were randomly divided into 2 groups：control group and therapy group,15 patients in each group.Patients in both groups received 2.5 mg/d of levamlodipine,and patients in therapy group were also given 60 mg/d of isosorbide mononitrate,the treatment for both groups lasted for 24 weeks.Result After treatment,the blood pressure of patients in both groups were decreased significantly（P0.05）,and the decrease range of therapy group was higher than control group.Conclusions ISMN-SR can significantly decrease SBP,and has less effect on DBP,then decrease PP and effectively decrease the blood pressure of elderly ISH patients,so it is effective in treatment of hypertension accompanied by coronary heart disease.
出处
《昆明医学院学报》
2011年第9期99-101,共3页
Journal of Kunming Medical College
