摘要
目的观察联合应用阿司匹林、阿托伐他汀、普罗布考(PAS疗法)对于动脉粥样硬化的疗效.方法随机将昆明医学院第二附属医院120例缺血性脑血管病合并颈动脉粥样硬化患者,将其分为PAS治疗组、AS对照组和A对照组,进行比较研究.PAS治疗组40例,应用普罗布考(0.5 g/d),阿司匹林(100mg/d),阿托伐他汀钙(20 mg/d);AS对照组40例,予阿司匹林(100 mg/d),阿托伐他汀钙(20 mg/d);A对照组40例仅给予阿司匹林(100 mg/d).共随访3个月,分别在治疗前,治疗后3个月检测血脂(TC、TG、LDL-C、HDL-C)及血清高敏C反应蛋白(hs-CRP),比较颈动脉内-中膜厚度(IMT)及颈动脉斑块积分的变化.结果治疗后PAS治疗组及AS对照组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及hs-CRP含量均下降(P<0.05),PAS治疗组更明显(P<0.01);PAS治疗组的颈动脉斑块积分有轻微下降趋势(P>0.05).结论 (1)阿司匹林、阿托伐他汀、普罗布考联合治疗动脉粥样硬化调脂、降低炎症指标hs-CRP效果明显优于单用阿司匹林,也较阿司匹林、阿托伐他汀联用效果明显;(2)稳定颈动脉粥样斑块需长期进一步观察才能得出结论.
Objective To investigate the effects of combination therapy of probucol,atorvastatin calcium and aspirin drugs（PAS）on patients with atherosclerosis.Method 120 patients with ischemic cerebrvascular disease and carotid arteriosclerosis were randomly divided into three groups：PAS group,AS group and A group,40 patients in each group.Patients in the PAS group were treated with probucol（0.5 g/d）,atorvastatin calcium（20 mg/d）and aspirin（100 mg/d）,patients in AS group were treated with atorvastatin calcium（20 mg/d）and aspirin（100 mg/d）,and patients in A group were given aspirin（100 mg/d）alone.All patients were followed up for 3 months.The serum lipids（TC,TG,LDL-C,HDL-C）,high-sensitivity C-reactive protein（hs-CRP）,intima-media thickness（IMT）of carotid arterial,carotid plaques score were measured before and three months after treatment.Results Serum total cholesterol（TC）,lowdensity lipoprotein-cholesterol（LDL-C）,hs-CRP levels in PAS group and AS group were reduced after treatment compared with that of before treatment（P0.05）,especially in PASgroup（P0.01）.Carotid plaques scrore was decreased slightly after treatment compared with that of before treatment（P0.05）.Conclusions（1）Combination therapy of probucol,atorvastatin and aspirin drugs can strengthen the effets on adjusting lipids and decreasing the level of inflammatory factor hs-CRP,furthermore the effects are stronger than that of combination therapy of probueol and atorvastatin and that of monotherapy whith aspirin.（2）The stability of carotid plaque needs long-term further observation in order to come to the conclusion.
出处
《昆明医学院学报》
2011年第9期28-33,共6页
Journal of Kunming Medical College
基金
国家自然科学基金资助项目(81060102)
博士启动基金资助项目(2007039)
云南省自然科学基金资助项目(2008CD018)
