摘要
目的探讨脑梗死患者血清白蛋白、球蛋白水平及其比值变化及对预后的影响。方法选择自2006年6月至2010年6月于兴义市人民医院神经内科住院治疗的120例急性脑梗死患者为研究对象Ⅰ组，选择同期具有脑血管病风险因素且与Ⅰ组危险因素匹配的110例个体为研究对象Ⅱ组，选择同期体检健康的90例志愿者为研究对象Ⅲ组。比较3组对象血清白蛋白、球蛋白、白蛋白／球蛋白比值、纤维蛋白原、外周血细胞的差异。随访2年后比较3组对象中白蛋白／球蛋白比值≥1．45及白蛋白／球蛋白比值〈1．45个体的预后差异。结果Ⅲ组、Ⅱ组及Ⅰ组血清球蛋白、纤维蛋白原、白细胞水平依次升高，组间比较差异有统计学意义（P〈0．05）；Ⅲ组、Ⅱ组及Ⅰ组血清白蛋白水平、白蛋白／球蛋白比值依次降低，组间比较差异有统计学意义（P〈0．05）。随访2年后Ⅰ组、Ⅱ组、Ⅲ组再发脑血管病发生率分别为24．1％、18．5％及2．3％，组间比较差异有统计学意义（P〈0．05）。Ⅰ、Ⅱ组白蛋白／球蛋白比值〈1．45亚组患者发生脑血管病事件风险是白蛋白／球蛋白比值≥1．45亚组患者的3．6倍。结论血清白蛋白、球蛋白水平及白蛋白／球蛋白比值与脑梗死发生密切相关．脑梗死及脑血管病危险人群白蛋白／球蛋白比值降低者较白蛋白／球蛋白比值正常者发生脑血管病事件风险增加。
Objective To explore the changes of serum albumin and globulin levels and albumin-globulin ratio in patients with cerebral infarction, and their prognostic value. Methods One hundred and twenty patients with acute ischemic stroke, admitted to our hospital from June 2006 to June 2010, were chosen as Group Ⅰ; Group Ⅱ included 110 subjects matched with Group Ⅰ for age, medications, and clinical risk factors of stroke; and Group Ⅲ was composed of 90 healthy volunteers, matched for age with Group Ⅰ and Ⅱ. Serum albumin and globulin levels, albumin-globulin ratio, fibrinogen level and number of peripheral blood cells in the 3 groups were compared; and the prognosis of subjects with an albumin-globulin ratio above 1.45 or less were compared between each 2 groups after 2-year-follow-up. Results Serum globulin, fibrinogen and leucocyte levels in Group Ⅰ were significantly higher than those in Group Ⅱ and Ⅲ, and those in Group Ⅱ were obviously higher than those in Group Ⅲ （P〈0.05）. Serum albumin level and albumin-globulin ratio in Group Ⅰ were significantly lower than those in Group Ⅱ and Ⅲ, and those in Group Ⅱ were obviously lower than those in Group Ⅲ （P〈0.05）. To the end of follow-up, the incidence of recurrent cerebrovascular disease were 24.1%, 18.5% and 2.3% in Group Ⅰ, Ⅱ and Ⅲ, respectively（P〈0.05）. Subjects with albumin-globulin ratio less than 1.45 in Group Ⅰ and Ⅱ had 3.6 times of risk for a subsequent vascular event as compared with their counterparts with albumin-globulin ratio above 1.45. Conclusion Serum albumin and globulin levels and albumin-globulin ratio have a close correlation with cerebral infarction. The patients with low albumin-globulin ratio have increased risk of cerebrovascular disease as compared with subjects of normal albumin-globulin ratio in subjects with cerebral infarction and high-risk cerebrovascular disease.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2011年第10期1023-1026,共4页
Chinese Journal of Neuromedicine
关键词
脑梗死
白蛋白
球蛋白
预后
Cerebral infarction
Albumin
Globulin
Prognosis
