摘要
目的:研究2型糖尿病对腰椎间盘突出症的发病率和严重程度的影响。方法:回顾性研究1999年10月至2008年10月间北京大学第一医院骨科手术治疗腰椎间盘突出症的病例575例(年龄40～70岁),确定合并2型糖尿病病例的数量和比例;选择同期、同年龄段手术治疗拇外翻、腕管综合征、肘管综合征和腱鞘囊肿病例219例作为对照组,确定合并2型糖尿病病例的数量和比例;应用χ2检验比较腰椎间盘突出症组和对照组合并2型糖尿病比例。将腰椎间盘突出症组分为合并2型糖尿病组和不合并2型糖尿病组两个亚组,观察两亚组病例腰椎间盘手术节段、腰椎间盘突出类型(包含型与非包含型)、术后是否复发行二次手术;应用独立样本t检验比较两亚组间腰椎间盘手术节段数量;应用χ2检验比较两亚组间腰椎间盘突出包含型和非包含型所占比例、术后复发行二次手术比例。结果:腰椎间盘突出症组的合并2型糖尿病的比例为15.3%(88/575),显著高于对照组7.76%(17/219,χ2=7.861,P=0.005),也高于北京地区40～70岁人群2型糖尿病发病率9.94%(188/1 892,χ2=12.788,P=0.000 4)。腰椎间盘突出症组亚组间比较结果为平均手术节段:合并2型糖尿病亚组1.19、不合并2型糖尿病亚组为1.15(t=0.703,P=0.483);腰椎间盘突出类型及比例:合并2型糖尿病亚组为包含型65.7%(58/88),非包含型34.3%(30/88),不合并2型糖尿病亚组为包含型70.5%(343/487),非包含型29.5%(144/487)(χ2=0.722,P=0.395);术后复发比例:合并2型糖尿病亚组为3.41%(3/88),不合并2型糖尿病亚组为3.89%(19/487,χ2=0.034,P=0.854)。结论:在手术治疗腰椎间盘突出症的中老年患者中,相比同龄行其他择期手术的患者合并2型糖尿病的比例增高,2型糖尿病可能增加腰椎间盘突出症的患病风险。
Objective：To analyze the influence of type 2 diabetes mellitus on incidence and severity of lumbar disc herniation.Methods： A total of 575 cases of lumbar disc herniation（40-70 years） from Orthopedic Department of Peking University First Hospital from October 1998 to October 2008 were retrospective studied,and the number and ratio of cases of type 2 diabetes mellitus identified.The control group included 219 cases of hallus valgus,carpal tunnel syndrome,cubital tunnel syndrome or ganglion.The number and ratio of cases of type 2 diabetes mellitus were also identified and the ratios of the two groups compared.Then we divided the lumbar disc herniation operation group into two subgroups,one with type 2 diabetes mellitus and the other without,and compared between the two subgroups the numbers of operation segments,the types of lumbar disc herniation（contained type and uncontained type） and the ratio of relapse with revision surgery by t test or χ2 test.Results： The ratio of lumbar disc herniation group with type 2 diabetes mellitus was 15.3%（88/575） and significantly higher than 7.76%（17/219）of the control group（χ2=7.861,P=0.005）,and also significantly higher than 9.94%（188/1892） of the incidence of type 2 diabetes mellitus in 40-70 years old people of Beijing（χ2=12.788,P=0.000 4）.The operation segments were 1.19 in subgroup with type 2 diabetes mellitus and 1.15 in subgroup without type 2 diabetes mellitus（t=0.703,P=0.483）;the ratios of different types of lumbar disc herniation were 65.7%（58/88）with contained type and 34.3%（30/88） with uncontained type in subgroup with type 2 diabetes mellitus as well as 70.5%（343/487） contained type and 29.5%（144/487） uncontained type in subgroup without type 2 diabetes mellitus（χ2=0.722,P=0.395）;the ratios of relapse cases with revision surgery were 3.41%（3/88） in subgroup with type 2 diabetes mellitus and 3.89%（19/487） in subgroup without type 2 diabetes mellitus（χ2=0.034,P=0.854）.Conclusion： People who received operation with lumbar disc herniation had the higher ratio concomitant with type 2 diabetes mellitus than the control group.Type 2 diabetes mellitus may increase the risk of suffering from lumbar disc herniation.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2011年第5期696-698,共3页
Journal of Peking University:Health Sciences
关键词
椎间盘移位
腰椎
糖尿病
2型
Intervertebral disk displacement
Lumbar vertebrae
Diabetes mellitus
type 2
