摘要
肝癌是常见的恶性肿瘤之一,其病程快且预后很差.其发生是一个多因素多步骤协同的复杂过程.近来的研究报道,肝癌发生分子机制与类胰岛素生长因子体系信号通路异常相关.类胰岛素生长因子是一种多功能细胞增殖调控因子,他在胚胎发育、中枢神经系统发育及肿瘤细胞增殖等方面具有重要的生物学功能.类胰岛素生长因子的生物学活性受到包括类胰岛素生长因子不同类型的受体、类胰岛素结合蛋白及类胰岛素结合相关蛋白等多因素参与的复杂的调控网络调控.本文主要介绍了类胰岛素生长因子体系在肝癌中的异常改变、类胰岛素生长因子相关信号通路及其作用机制以及在肝癌靶向治疗中的应用.
Hepatocellular carcinoma （HCC） is one of the most malignant types of cancer. It has a rapid course and carries a poor prognosis. Hepatocarcinogenesis is a complex multi-step and multi- factorial process. Recent studies have discovered the association between the dysregulation of insulin-like growth factor （IGF）-related signaling pathways and pathogenesis of liver cancer. IGFs are multifunctional cell proliferation regulatory factors and play an important role in fetal development, central nervous system development and cancer cell proliferation. The biological activity of IGFs is regulated by a complex regulatory network which consists of different types of receptors, IGF-binding proteins and IGF binding-related proteins. This review focuses on the changes in the IGF axis and IGF-related signaling pathways in liver tumorigenesis and their application in targeted therapy for liver cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第23期2473-2479,共7页
World Chinese Journal of Digestology
关键词
类胰岛素生长因子
类胰岛素生长因子受体-I
肝癌
Insulin-like growth factors
Insulin-likegrowth factor-I receptor
Hepatocellular carcinoma
