摘要
目的研究老年女性2型糖尿病患者骨量及骨代谢生化指标的变化。方法运用QCT测定42例正常老年女性以及31例确诊为2型糖尿病的老年女性患者的腰椎松质骨密度,检测糖化血红蛋白(糖尿病组)、胰岛素及C肽(空腹及餐后2h)、性激素、血钙、磷、总碱性磷酸酶、骨钙素及尿脱氧吡啶啉、尿钙、磷。结果①老年女性2型糖尿病组骨密度与年龄相匹配的对照组比较无显著差异(P>0.05);②老年女性糖尿病组Dpd及BGP水平均高于对照组(P<0.05),而雌二醇水平低于对照组(P<0.05)。结论老年女性2型糖尿病患者与正常老年女性相比骨密度无明显差异;血BGP及尿Dpd是老年女性2型糖尿病患者骨代谢紊乱的敏感指标。
Objective To study the changes of bone mineral density and bone metabolic marker in elderly females with type 2 diabetes mcllitus. Methods The trabecular bone mineral density of the lumbar spines in 42 elder female controls and 31 elder females with type 2 diabetes mellitus was measured using QCT. Hemoglobin Alc （HbAlc） in type 2 diabetes mellitus patients, insulin （Ins） and C-peptide （ CP, fasting and 2h after meals）, sex hormone, serum calcium （Ca） and phosphorus （P）, alkaline phosphatase （ ALP）, bone gla protein （ BGP）, D-Pyridnoline （ Dpd）, urinary calcium （UCa） and phosphorus （UP） were measured. Results 1 ） No significant difference of BMD was found between elderly females with type 2 diabetes mellitus and age-matched controls （ P 〉 0.05）. 2） The levels of Dpd and BGP in elderly females with type 2 diabetes mellitus were higher than those of controls （ P 〈 0. 05） , but the estrogen level was lower （P 〈 0.05）. Conclusion No significant difference of BMD was found between elderly females with type 2 diabetes mellitus and normal elderly women. Serum BGP and urinary Dpd are sensitive markers of the bone metabolic disorders.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第10期860-862,878,共4页
Chinese Journal of Osteoporosis
关键词
老年女性
2型糖尿病
骨密度
骨代谢生化指标
Elderly female
Type 2 diabetes mellitus
Bone mineral density
Bone metabolic markers
