摘要
目的:探讨布地奈德与氨茶碱联合治疗慢性阻塞性肺部疾病(COPD)患者疗效及对肺功能的影响。方法:将确诊的COPD患者随机分为观察组和对照组各43例。2组患者均给予控制感染、解痉平喘、止咳化痰、纠正电解质及酸碱平衡紊乱等对症治疗。对照组在上述常规治疗基础上加用氯茶碱;观察组在对照组治疗基础上予以布地奈德雾化液雾化吸入。结果:观察组总有效率为88.37%,对照组总有效率为69.77%,2组总有效率比较差异有统计学意义(P<0.05);2组患者治疗后用力肺活量(FVC)、1秒钟用力呼气容积(FEV1)及1秒钟用力呼气容积占用力肺活量百分比(FEV1/FVC%)明显优于治疗前,治疗前后比较差异有统计学意义(P<0.05,或P<0.01);治疗后观察组FVC、FEV1、FEV1/FVC%改善情况与对照组比较差异均有统计学意义(P<0.05)。结论:氨茶碱和布地奈德吸入联合治疗COPD,能够改善肺功能,提高临床疗效,值得推广使用。
Objective：To explore the effectiveness of the combination between budesonide and aminophylline in patients with chronic obstructive lung disease （COPD） and its effect on lung function. Methods： The definite patients with COPD were randomly allocated into two groups including observation group and control group, each of which had 43 cases. In two groups, all patients received a series of symptomatic treatment such as infectious control, spasmolysis and antiasthmatic treatment, relieving cough and reducing sputum and rectifying disturbance of electrolyte and acid-base balance. In control group, the patients received aminopbylline as an additional treatment. Except for that, the patients also inhaled the budesonide atomized liquid in observation group. Results： The total effective rate in observation group was 88.37%, while it was 69.77% in control group. There was significant difference between two groups. The forced vital capacity （FVC）, forced expiratory volume at one second （FEVI） and the ratio of forced expiratory volume to forced vital capacity （FEV 1/FVC %） significantly surpassed those before treatment （P〈0.05 or P〈0.01）. Besides, for the improvement of FVC, FEV1, FEV1/FVC%, there was statistical significance between two groups （P〈0.05）. Conclusions： The inhalation therapy of aminophylline and budesonide can treat COPD, improve lung function, evaluate the clinical effectiveness and deserve to be generalized.
出处
《中国医药导刊》
2011年第9期1542-1543,共2页
Chinese Journal of Medicinal Guide
