摘要
目的:研究TP/PD-ECGF在胃癌中的表达情况,并对其与胃癌患者临床病理特征和预后的关系进行探讨。方法:采用免疫组化EnVision两步法检测107例胃癌组织中TP/PD-ECGF的表达,并分析其与胃癌患者临床病理特征及预后的关系。结果:胃癌患者中TP/PD-ECGF阳性表达率为71.0%。TP/PD-ECGF表达与肿瘤分期、淋巴结转移、远处转移及分化程度呈正相关。TP/PD-ECGF阳性与阴性表达患者3年、5年总生存率分别为69.04%、18.12%和88.87%、75.20%,二者差异有统计学意义(P=0.0383)。Cox比例风险模型多因素分析显示,肿瘤分期、淋巴结转移、远处转移及TP/PD-ECGF均是影响胃癌预后独立的危险因素。结论:TP/PD-ECGF在胃癌组织中呈高表达,与胃癌生长和浸润转移关系密切,可作为胃癌独立的预后因素。
Objective：Thymidine phosphorylase/Platelet-derived endothelial cell growth factor （TP/PD-ECGF） has shown to be upregulated in several cancers and to play an important role in angiogenesis and invasion of solid tumors,This study was to detect the expression of TP/PD-ECGF,and investigate its influence on the clinicopahtological characteristics and the prognosis m gastric carcinoma patients. Methods：The expression of TP/PD-ECGF in 107 specimens of gastric carcinoma was examined by EnVision immunohistochemistry.The correlation of the expression of TP/PD-ECGF to the clinieopathologieal characteristics and the prognosis m gastric carcinoma patients were analyzed.Results：The positive expression rate of TP/PD-ECGF was 71.0% in gastric carcinoma.The expression of TP/PD-ECGF were positively correlated to the stage of primary tumor, lymph node metastasis,distant metastasis and histological grade.The 3-year and 5-year overall survival rates were significant lower in the patients with positive expression of TP/PD-ECGF than in those with negauve expression of TP/PD-ECGF （69.04% vs. 88.87%,18.12% vs. 75.20%,P=0.0383）.Multivariate Cox model analysis showed that the stage of primly tumor, lymph node metastasis,distant metastasis and TP/PD-ECGF were the independent prognostic factors for the patients with gastric carcinoma.Conelusion：TP/PD-ECGF is overexpressed in gastric carcinoma, and related with the growth, invasion and metastasis of gastric carcinoma,and it is an independent prognostic indicator of survival in patients with gastric carcinoma
出处
《中国医药导刊》
2011年第7期1235-1237,共3页
Chinese Journal of Medicinal Guide
关键词
胃癌
血小板衍化内皮细胞生长因子
预后
Gastric neoplasm
Thymidine phosphorylase/platelet-derived endothelial cell growth factor
Prognosis
