摘要
目的:从心肌细胞电生理的角度探讨血管紧张素Ⅱ受体阻断剂(ARB)类药物抗房颤的可能机制。方法:采用全细胞膜片钳技术的电压钳方法记录心房肌细胞的延迟整流钾电流(Ik)。观察ARB类药物缬沙坦对豚鼠心房肌细胞离子通道电流的影响。结果:缬沙坦100μ明显抑制心房肌细胞IK的峰值电流,从(5.33±0.13)p_A/pF减小至(4.49±0.48)pA/pF,P<0.05,并呈电压依赖性。结论:缬沙坦抑制心房肌细胞延迟外向钾电流,可能是引起其动作电位时程延长的一个重要因素。缬沙坦延长心房肌动作电位时程,可能在房颤的转复及房颤转复后窦性心律的维持中有价值。
Objective：To study the pOtential mechanism of angioteasin iI blocker（ARB）on atrial fibrillation from Cellular electrophysiology point of view,Method：Whole-ceil patch clamptechnique was adopted.Patch-clamp mode was used to record dolayod rectifier K^＋ currents （Ik） of guinea pig atrial myocytes.Results：Valsartan 100μM reduced atrial myocytes peak Ik current From （5.33 ± 0.13）nA/pF to （4.49 ± 0.48）pA/pF, voltage dependenfly.Conclusion：Inhibiting Ik by valsartan is an important factor contributing to the prolongation of APD.By prolonging APD.valsartan may have potential in converting AF to sinus rhythm or in maintaining sinus rhythm after successful convertion.
出处
《中国医药导刊》
2011年第7期1224-1225,共2页
Chinese Journal of Medicinal Guide
关键词
缬沙坦
钾电流
心房肌
Valsartan Potassium cunrrent Atrial myoeytes
