摘要
目的探讨注射用磷酸肌酸钠能否减轻表阿霉素化疗引起的心脏毒性。方法治疗组40例于化疗的同时,应用注射用磷酸肌酸钠静滴,并用含表阿霉素的方案联合化疗;对照组40例单用化疗。结果治疗组与对照组比较,总有效率为35.0%,对照组为32.5%(P>0.05);两组治疗后心脏节律异常率为12.5%VS 50.0%(P<0.05);心功能损害发生率为7.5%VS 32.5%;治疗组治疗后左室射血分数高于对照组(P>0.05)。结论注射用磷酸肌酸钠不影响抗肿瘤效果,能降低表阿霉素方案化疗所致心脏毒性的发生率,改善化疗患者的生活质量。
Objective To discuss whether creatine phosphate sodium for injection in reducing cardiac toxicity induced by epirubicin.Methods The treatment group（40 cases） and the control group（40 cases） were treated with adriamycin.At the same time,the treatment group were given creatine phosphate sodium for injection.Results The total effective rate of the treatment group and the control group were 35% and 32.5%,respectively（P0.05）;the incidence rate of heart rhythm abnormality were 12.5% and 50.0%,respectively（P0.05）;the incidence rate of cardiac dysfunction were 7.5% and 32.5%,respectively;left ventricular ejection fraction of the treatment group was higher than that of the control group（P0.05）.Conclusion Creatine phosphate sodium for injection could reduce the incidence of cardiac toxicity induced by epirubicin and improve the quality of life of the patients without weakening therapeutic effect.
出处
《黑龙江医学》
2011年第10期772-774,共3页
Heilongjiang Medical Journal
