摘要
目的:探讨急性颅脑损伤(TBI)后血清中白介素-8(IL-8)的含量变化及其意义。方法:采用ELISA法检测48例TBI患者不同时间血清IL-8含量,按GCS评分分组并与对照组比较,进行统计学分析。结果:TBI患者组IL-8在发病后24h、3天、5天的血清水平显著高于对照组(P<0.05),发病后血清IL-8水平与入院时GCS评分呈负相关。结论:IL-8参与了TBI后的病理生理过程,其测定对于评估脑损伤的严重程度和预后有重要的临床意义。
Objective： To explore the changes traumatic brain injury （TBI）. Methods： The serum and the clinical significance of serum IL-8 in patients with acute content of IL-8 from 48 patients with TBI at different time after injury were measured by ELISA and grouped by GCS score, made statistical analyses compared with the control group. Results： The serum levels of IL-8 were significantly higher than those in the control group （P〈0.05）on the 24 h, 3rd,5th days after TBI. The serum levels of IL-8 were negatively correlated with the GCS scores after injury. Conclusions： IL-8 is involved in the pathological process of TBI, and the detection of the serum levels are important for evaluation of the severity of injury and predicition of outcomes.
出处
《岭南急诊医学杂志》
2011年第5期351-352,共2页
Lingnan Journal of Emergency Medicine
基金
2010年山西省高校科研基金资助 (20101141)
关键词
颅脑损伤
白介素-8
临床意义
traumatic brain injury
IL-8
clinical significance
