摘要
目的探讨丹参多酚酸盐对老年不稳定型心绞痛患者血浆炎症细胞因子及内皮素的影响。方法老年不稳定型心绞痛患者72例随机分为基础组（n=36）和实验组（n=36），基础组采用常规治疗，实验组在常规治疗的基础上辅以丹参多酚酸盐注射液治疗14d，并以22例健康老年人做对照。分别测定各组治疗后临床效果、心电图ST改变，以及血清炎症细胞因子水平和血浆内皮素（ET）水平变化。结果：（1）14d治疗后，按照心绞痛疗效评定标准及心电图疗效评定标准，实验组较基础组总有效率增加（19〈0．05）；（2）老年不稳定心绞痛患者血清白细胞介素1（IL-1）以及可溶性细胞间黏附分子-1（sICAM-1）以及血浆ET水平升高（P〈0．05）；治疗14d后，与同期基础组相比较，实验组血清IL-1、sICAM-1，以及血浆ET降低（P〈0．05）。结论丹参多酚酸盐注射液能降低老年不稳定型心绞痛患者血浆炎症细胞因子，抑制炎症反应，改善血管内皮细胞功能。
Objective To investigate the effect of salvianolate on the serum cytokines and endothelin levels in elderly patients with unstable angina pectoris （UAP）. Methods 72 patients were randomly divided into conventional treatment group （n = 36） and salvianolate treatment group （n = 36）. The levels of interleukin-1 （IL-1）, intercellular adhesion molecular （ICAM-1） and endothelin （ET） were evaluated before therapy and 14 days after therapy. The levels of the cytokines and ET were compared with normal control group （n=22）. Results （1） The levels of serum IL-1, slCAM-1 and ET in patients with UAP were higher than the normal control group （P〈 0.05）; （2） Thelevels of serum IL-1 and slCAM-1 were decreased after treatment with salvianolate treatment, with more significant effect compared with conventional treatment group （P〈0.05） . Conclusions IL-1 and sICAM-1 amd ET might be involved in the development of unable angina pectoris. Salvianolate can decrease inflammatory cytokines and endothelin in elderly patients with UAP.
出处
《老年医学与保健》
CAS
2011年第5期312-314,共3页
Geriatrics & Health Care
