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单股正链RNA病毒3'非编码区的结构与功能研究进展

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摘要 单股正链RNA病毒基因组中的3'非编码区(3'UTR)可以形成二级或者高级结构,这些结构对维持病毒RNA的稳定性以及病毒的复制调控具有至关重要的作用。它不仅可以单独发挥作用,也可以与RNA或者蛋白相互作用调控病毒的复制、转录、翻译和包装等各个过程。本文对RNA结构和功能研究的一般方法,以及一些单股正链RNA病毒代表种属的3'UTR的结构和功能进行了综述,并且就研究前景和一些存在的问题进行了探讨。
作者 刘萍 刘长龙 陆嘉琦 高飞 尹杨 姚火春 袁世山
机构地区 南京农业大学动物医学院 中国农业科学院上海兽医研究所/中国动物卫生与流行病学中心上海分中心猪传染病研究室/农业部动物寄生虫病重点实验室
出处 《畜牧与兽医》 北大核心 2011年第10期98-102,共5页 Animal Husbandry & Veterinary Medicine
基金 国家自然科学基金面上项目(30972204) 国家重点基础研究发展计划"973计划"(2005CB523202) 上海市自然科学基金项目(08ZR1422800)
关键词 单股正链RNA病毒 3′UTR 结构与功能 病毒复制
分类号 S852.65 [农业科学—基础兽医学]
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参考文献38

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畜牧与兽医
2011年 第10期

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