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同种异体复合组织移植的免疫研究进展 被引量：2

RESEARCH PROGRESS IN IMMUNE OF COMPOSITE TISSUE ALLOTRANSPLANTATION
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摘要 目的了解同种异体复合组织移植的免疫研究进展。方法查阅相关文献,对同种异体复合组织移植的免疫特点、实验进展、临床经验等进行总结。结果同种异体复合组织位于体表,包含组织成分复杂,抗原性高。其移植后在免疫抑制剂用药方案、排斥反应的诊断以及慢性排斥反应发生率等许多方面同内脏器官移植有不同的特点。结论在下一步研究中,应吸取同种异体复合组织移植独特的经验教训,在诱导耐受、局部用药、排斥诊断等方面树立同种异体复合组织的独特标准。 Objective To introduce the research progress in the immune of composite tissue allotransplantation.Methods The related articles were reviewed to summarize the immune characteristics,experimental developments,and clinical experiences of composite tissue allotransplantation.Results Composite allogeneic tissue is on the body surface,including the composition of the complex with high antigenicity.There are a lot of differences in the immune responses between composite tissue allotransplantation and organ transplantation,such as immunosuppressant protocol,rejection diagnosis,and chronic rejection.Conclusion In the next study,it is urgently needed to learn these experiences and to establish the special standard of composite tissue allotransplantation in induction of immune tolerance,local medication,and rejection diagnosis.
作者 肖博 郭树忠
机构地区 第四军医大学西京医院整形外科
出处 《中国修复重建外科杂志》 CAS CSCD 北大核心 2011年第10期1261-1265,共5页 Chinese Journal of Reparative and Reconstructive Surgery
关键词 同种异体复合组织移植 免疫排斥反应 动物模型 免疫耐受 排斥标准 Composite tissue allotransplantation Immune rejection response Animal model Immune tolerance Rejection standard
分类号 R617 [医药卫生—外科学]
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参考文献62

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同被引文献30

  • 1Ravindra K V, Xu H, Ildstad S T. Vascularized composite allotransplantation at a crossroad [J]. Transplant Proc,2011,43(9):3501-3503.
  • 2Barth R N, Rodriguez E D, Mundinger G S, et al. Vascularized bone marrow-based immunosuppression inhibits rejection of vascularized composite allografts in nonhuman primates [J]. Am J Transplant, 2011,11(7): 1407-1416.
  • 3Huang W C, Lin J Y, Wallace C G, et al. Vascularized bone grafts within composite tissue allotransplants can autocreate tolerance through mixed chimerism with partial myeloablative conditioning: an experimental study in rats [J]. Plast Reconstr Surg,2010,125(4):1095- 1103.
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  • 10Agaoglu G, Unal S, Siemionow M. Transplantation of the vascularized bone allograft into the inguinal region[J]. Plast Reconstr Surg,2005,115(6):1794-1795.

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中国修复重建外科杂志
2011年 第10期

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