摘要
目的探讨伴t(16;21)(p11;q22)的恶性血液病的临床及实验室特征。方法骨髓细胞24 h培养后按常规方法制备染色体,用RHG显带技术进行细胞遗传学分析。结果 1例M2的患者其核型分析结果有t(16;21)(p11;q22)的异常,临床和血液学改变符合急性髓细胞白血病-M2a诊断,化疗后未获得完全缓解,中位生存期为6个月。结论 t(16;21)(p11;q22)是一类很独特的白血病亚型有关的易位,为少见的非随机的染色体易位,其临床预后差。
Objective To investigate the clinical and laboratory characteristics of hematological malignancies with t（16;21）（p11;q22） translocation.Methods Bone marrow cell chromosome specimens were carried out by short-term culture,and chromosome karyotype analysis was made by RHG banding technique.Results The chromosome karyotype analysis of one leukemia patient had t（16;21）（p11;q22） translocation.The leukemia type of this patient was AML-M2a which was identified by clinic and hematological observation.This patient did not obtain complete remission after chemotherapy and the median survival time was 6 months.Conclusion t（16;21）（p11;q22） translocation is a rare and recurring chromosome abnormality,which is related to a specific type of AML.The prognosis of the AML patients with this chromosome abnormality is poor.
出处
《检验医学与临床》
CAS
2011年第20期2440-2441,共2页
Laboratory Medicine and Clinic
基金
广州医学院博士专项基金资助项目(092402)
关键词
染色体
易位
细胞遗传学
急性白血病
chromosome
translocation
cytogenetics
acute myeloid leukemia
