摘要
苄基四氢巴马汀(benzyltetrahydropalmatin,BTHP)是四氢巴马汀的衍生物,剂量1～10mg/kg有抗多种实验性心律失常的作用,对大鼠心缺血—复灌所致心律失常也有效。本文观察BTHP对在位猫心缺血—复灌时单相动作电位(MAP)变化的影响。
The changes of monophasic action potential (MAP) in ischemic and reperfused feline ventricle in siiu were studied. When the feline coronary artery was ligated the MAPD_(50) was found to be markedly shortened, the T wave and S-T segment were elevated evidently. Within seconds of releasing the coronary occlusion ventricular fibrillation and death occurred in all animals.
Intravenous injection of BTHP markedly prolonged the MAPD_(50) and MAPD_(90) and reduced the heart rate, while no influence on T wave and S-T segment were observed. After occlusion of the coronary artery, the T wave and S-T segment only increased slightly and the MAPD_(50) recovered to its control level. During reperfusion the occurrence of ventricular fibrillation was significantly reduced.
In contrast, prazosin, verapamil and propranolol did not show significant effect on changes of MAP, but BTHP and Pra, Ver and Pro all showed protective effect on feline isohemic and reperfused myocardia by ligation and reperfusion of the coronary (?)rtery with decrease of the number of arrhythmia, ventricular fibrillation and death.
The order of antiarrhythmic action of these agents was BTHP=Pra>Ver>Pro. The total incidence of ventricular fibrillation reduced from the control values of 100% in ischemia/reperfusion heart to 0% (BTHP and Pra),20% (Ver) and 40% (Pro).
出处
《药学学报》
CAS
CSCD
北大核心
1990年第4期293-296,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
四氢巴马汀
心律失常
动作电位
Tetrahydropalmatine
Arrhythmia
Myocardium ischemia
Monophasic action potential
