摘要
以瓜尔胶-g-聚丙烯酸/麦饭石复合水凝胶(GG-g-PAA/MS)和海藻酸钠(SA)为原料,双氯芬酸钠(DS)为模拟药物,采用离子凝胶法制备了载药复合凝胶小球,考察了pH敏感性以及MS含量对复合凝胶小球的包封率、载药率、溶胀性和药物释放行为的影响。结果表明:凝胶小球具有明显的pH敏感性,在不同pH介质中溶胀率和释放速率不同,在模拟胃液中基本不释放药物,而转入模拟肠液2h后其药物累积释放率就超过了60%;另外,与不含MS的样品相比,随着MS的增加,包封率、载药率、溶胀率和药物累积释放率而减小,表明在载药凝胶小球中引入MS,可以减缓药物的突释效应。
A novel guar gum-g-poly（acrylic acid）/medicinal stone/sodium alginate（GG-g-PAA/MS/SA）hydrogel beads were prepared by the ionic gelation technique.Effects of MS content on the swelling property,encapsulation efficiency and drug release behaviors were investigated using diclofenac sodium（DS）as a model drug.pH-sensitive properties and in vitro release kinetics of DS from the hydrogel beads were also studied.The results showed that DS was hardly released from the hydrogel beads in simulated gastric fluid,however,the cumulative release ratio was over 60%in simulated intestine fluid after 2h,which indicated that the hydrogel beads had good pH-sensitive.In addition,the encapsulation efficiency,swelling ratio and DS cumulative release were slowed down obviously with increasing MS content of the prepared hydrogel beads,which revealed that incorporating MS into the hydrogel beads can improve the burst release effect of the drug.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2011年第10期1341-1345,共5页
Chemical Research and Application
基金
中国科学院"优秀博士学位论文
院长奖获得者科研启动专项资金"资助项目(2008-06)
关键词
麦饭石
凝胶小球
PH敏感性
控制释放
双氯芬酸钠
medical stone
hybrid composite
pH-sensitive
controlled release
diclofenac sodium
